Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7457.094 | uM | 0.00051 | 0.00078 | -0.8956 | -0.6816 | 2.0313 | 1.5901 | 0.9463 | 1.8462 | |
AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9035.001 | uM | 0.00071 | 0.00076 | 0.2153 | -0.1767 | 5.0000 | 0.9858 | 0.7915 | 2.4291 | |
BT-483 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 5908.069 | uM | 0.00124 | 0.00074 | 0.1221 | 0.1875 | 0.9066 | 0.6615 | 0.9618 | 0.6014 | |
HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7841.001 | uM | 0.00065 | 0.00073 | -0.7519 | -0.1312 | 2.0815 | 0.9082 | 0.6730 | 0.5424 | |
MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7904.001 | uM | 0.00066 | 0.00071 | -0.0087 | -0.2074 | 5.0000 | 1.0124 | 0.6937 | 1.3917 | |
HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 7839.001 | uM | 0.00067 | 0.00070 | -0.4867 | -0.1112 | 5.0000 | 0.8932 | 0.8549 | 1.8919 | |
T47D | HR+ | Luminal | Torkinib | 15340.211 | uM | 0.00038 | 0.00069 | -0.2049 | -0.1299 | 0.3943 | 0.8877 | 0.9641 | 1.5685 | |||
SUM52PE | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7541.095 | uM | 0.00031 | 0.00056 | -0.9787 | -0.3061 | 0.7899 | 1.0595 | 0.6623 | 1.4542 | |
UACC-812 | HER2amp | Luminal | Torkinib | 15404.211 | uM | 0.00005 | 0.00056 | -0.8141 | -0.8007 | 0.3960 | 1.4387 | 0.9967 | 0.5754 | |||
HMT-3522 S1 | Unknown | Unknown | Trametinib | MEK | MAPK | 10124.012 | uM | 0.00074 | 0.00053 | 0.2498 | 0.2658 | 2.3479 | 0.6006 | 0.9280 | 1.9565 | |
BT-549 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7803.042 | uM | 0.00050 | 0.00052 | -0.5972 | -0.0656 | 2.5414 | 0.9089 | 0.7256 | 2.8270 | |
T47DKBLUC | Unknown | Unknown | Torkinib | 15360.211 | uM | 0.00023 | 0.00037 | -0.1763 | -0.1097 | 0.4213 | 0.9138 | 0.9795 | 0.8772 | |||
SUM44PE | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7538.068 | uM | 0.00014 | 0.00030 | -0.2424 | -0.1582 | 0.3753 | 1.0105 | 0.7167 | 0.8203 | |
HCC1954 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7837.042 | uM | 0.00015 | 0.00026 | -0.8248 | -0.4139 | 1.1755 | 1.2659 | 0.6601 | 1.6916 | |
HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7463.068 | uM | 0.00019 | 0.00017 | -0.0655 | 0.0169 | 0.3266 | 0.8520 | 0.8086 | 0.5887 | |
HCC3153 | TNBC | Basal A | Ro 32-0432 | PKC | PKC | 10577.142 | uM | inf | 0.00015 | 0.8665 | 0.8748 | 5.0000 | 0.1168 | 0.5822 | 1.0584 | |
MCF7 | HR+ | Luminal | Torkinib | 15394.211 | uM | 0.00006 | 0.00015 | -0.2414 | -0.2040 | 0.3606 | 1.0163 | 0.9695 | 1.8299 | |||
SUM1315MO2 | TNBC | Basal B | Torkinib | 15401.211 | uM | -inf | 0.00012 | -0.9603 | -0.8964 | 0.4331 | 1.6631 | 0.9588 | 0.4079 | |||
ZR-75-1 | HR+ | Luminal | Torkinib | 15346.211 | uM | 0.00002 | 0.00009 | -0.6847 | -0.6526 | 0.5569 | 1.5120 | 0.9820 | 0.6395 | |||
MDA-MB-468 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7906.018 | uM | 0.00003 | 0.00009 | -0.9241 | -0.7076 | 0.8524 | 1.6148 | 0.7919 | 0.9087 | |
HCC70 | TNBC | Basal A | Torkinib | 15390.211 | uM | -inf | 0.00003 | -0.9960 | -0.9803 | 0.5245 | 1.8586 | 0.9905 | 0.5021 | |||
BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10261.131 | uM | -inf | 0.00002 | -0.3245 | -0.3912 | 0.1000 | 1.0766 | 0.7849 | 2.3992 | |
BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9163.026 | uM | inf | 0.00002 | 0.8122 | 0.8820 | 4.9564 | 0.0838 | 0.5768 | 0.3738 |