Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 7932.001 | uM | 8.94240 | 7.61130 | 0.2743 | 0.2737 | 4.9198 | 0.1129 | 0.8952 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 7932.001 | uM | inf | inf | -0.2938 | -0.2938 | 0.0000 | 0.1774 | 0.3309 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12003.169 | uM | inf | inf | 0.7172 | 0.7172 | 0.0000 | 0.1350 | 0.4074 | 1.0562 | ||
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7931.011 | uM | 0.05667 | 0.02512 | 0.3168 | 0.4236 | 2.3080 | 0.3854 | 0.9628 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 11660.15 | uM | 12.39430 | 999.99110 | 0.4393 | -0.8020 | 0.2180 | 0.2429 | 0.8326 | 0.9958 | ||
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9958.012 | uM | 0.05477 | 0.06902 | -0.3984 | -0.3592 | 2.3412 | 0.7512 | 0.9975 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 7931.04 | uM | 0.12349 | 0.12268 | -0.0219 | 0.0163 | 5.0000 | 0.5033 | 0.9942 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7932.011 | uM | 0.02338 | 0.02080 | -0.0531 | 0.1219 | 2.3909 | 0.5838 | 0.9535 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 7553.096 | uM | inf | inf | 0.8456 | 0.8456 | 0.0000 | 0.1005 | -0.1404 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9958.001 | uM | inf | inf | -0.6349 | -0.6349 | 0.0000 | 0.4214 | 0.4925 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7552.095 | uM | 0.45694 | 0.82765 | -0.9734 | -0.9844 | 1.8318 | 0.6203 | 0.9968 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12003.166 | uM | 1.95110 | 169.06310 | -0.0471 | -1.0000 | 0.2462 | 0.3907 | 0.7596 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 11660.149 | uM | inf | inf | 0.7903 | 0.7903 | 0.0000 | 0.1532 | 0.0592 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11660.154 | uM | inf | inf | 0.8493 | 0.8493 | 0.0000 | 0.1199 | -0.0998 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7552.084 | uM | 0.31911 | 0.48962 | -0.9725 | -0.9736 | 2.5248 | 0.6601 | 0.9969 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Everolimus | MTOR | MTOR | 12003.164 | uM | 0.02561 | 0.03003 | -0.1277 | -0.0475 | 0.5701 | 0.6142 | 0.9704 | 0.9505 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7553.085 | uM | 0.35299 | 0.58389 | -0.9753 | -0.9726 | 2.1463 | 0.6085 | 0.9994 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12003.167 | uM | inf | inf | 0.7304 | 0.7304 | 0.0000 | 0.2250 | -0.0343 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7553.091 | uM | inf | inf | 0.9665 | 0.9665 | 0.0000 | -0.0228 | -0.3323 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7932.017 | uM | 0.22602 | 0.25841 | -0.9909 | -0.4768 | 5.0000 | 0.7307 | 0.9014 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7553.074 | uM | 2.04560 | 7.01310 | -0.4013 | -0.5183 | 0.5773 | 0.4802 | 0.9831 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7931.007 | uM | 0.18587 | 1.63760 | -0.6773 | -0.7919 | 0.4363 | 0.5803 | 0.9436 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7932.043 | uM | 0.12271 | 0.25988 | -0.7083 | -0.5033 | 0.9281 | 0.6673 | 0.9471 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9958.002 | uM | 0.00820 | 0.00391 | 0.2081 | 0.3160 | 1.3506 | 0.4063 | 0.9652 | 0.5113 | |
| ZR-75-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 7932.002 | uM | 0.02764 | 0.00527 | 0.4929 | 0.4679 | 1.6551 | 0.2991 | 0.9428 | 0.8992 |