Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7812.04 | uM | 4.6730 | 5.92090 | -0.2506 | -0.2552 | 1.7425 | 0.3049 | 0.9762 | 1.0573 | |
| HCC1187 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10753.143 | uM | 89.89790 | 1000.00000 | -0.1974 | -0.5152 | 0.2940 | 0.3648 | 0.7850 | 1.4954 | |
| HCC1187 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7811.017 | uM | 12.20530 | 48.34130 | -0.9997 | -1.0000 | 0.7982 | 1.0316 | 0.9194 | 0.3604 | |
| HCC1187 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7812.017 | uM | 505.4030 | 1000.00000 | -0.8283 | -0.6532 | 1.2246 | 0.3272 | 0.9679 | 1.1362 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 7433.066 | uM | 49.0820 | 39.44790 | 0.7887 | 0.3207 | 4.6933 | -0.0151 | 0.7750 | 1.0755 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 7431.066 | uM | inf | 6.29190 | 0.6023 | 0.6021 | 4.9962 | 0.0616 | 0.9181 | 1.1865 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 7432.066 | uM | inf | 6.60440 | 0.6582 | 0.6581 | 5.0000 | 0.0190 | 0.9284 | 0.9987 | |
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7811.044 | uM | inf | inf | 0.9811 | 0.9811 | 0.0000 | 0.0159 | -0.0256 | 0.3073 | |
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7812.016 | uM | inf | 0.03633 | 0.7129 | 0.7912 | 4.9997 | 0.1273 | 0.8061 | 1.0628 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 10518.141 | uM | 1.80660 | 1.25980 | 0.1622 | 0.1140 | 0.7180 | 0.2657 | 0.9263 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 10753.153 | uM | 1.86320 | 2.3770 | 0.0840 | -0.0820 | 0.6233 | 0.2388 | 0.9612 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 7431.072 | uM | 62.80280 | 6.10020 | 0.4573 | 0.4206 | 0.7892 | 0.1453 | 0.9353 | 1.4372 | |
| HCC1187 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 10518.072 | uM | 8.05840 | 44.66590 | -0.4627 | -1.0000 | 0.6415 | 0.3266 | 0.9675 | 1.2152 | |
| HCC1187 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 10753.072 | uM | 12.25950 | 39.21030 | -0.6332 | -1.0000 | 0.9449 | 0.3036 | 0.9852 | 1.3367 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 15300.203 | uM | 0.00104 | 0.00168 | -0.9901 | -0.9929 | 2.2895 | 1.6434 | 0.9968 | 0.8443 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7431.074 | uM | 0.03153 | 0.04619 | -0.9365 | -0.9373 | 2.7635 | 1.2473 | 0.9990 | 1.4349 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7431.074 | uM | 0.03153 | 0.04619 | -0.9365 | -0.9373 | 2.7635 | 1.2473 | 0.9990 | 1.4349 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7432.074 | uM | 0.01535 | 0.02166 | -0.9993 | -0.9985 | 3.1914 | 1.3750 | 0.9993 | 0.8598 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7432.074 | uM | 0.01535 | 0.02166 | -0.9993 | -0.9985 | 3.1914 | 1.3750 | 0.9993 | 0.8598 | |
| HCC1187 | TNBC | Basal A | Bosutinib | Src | nRTK | 10753.145 | uM | 3.19730 | 5.23050 | -0.3854 | -0.4409 | 1.2844 | 0.3743 | 0.9784 | 1.5180 | |
| HCC1187 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7811.011 | uM | 9.34130 | 15.53130 | -0.9999 | -1.0000 | 2.1609 | 0.7396 | 0.9934 | 0.4400 | |
| HCC1187 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 9244.021 | uM | 28.070 | 34.96690 | -0.9998 | -0.9999 | 5.0000 | 0.5650 | 0.9980 | 0.4542 | |
| HCC1187 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7812.011 | uM | 27.99240 | 39.95870 | -0.9731 | -0.9495 | 2.9906 | 0.5264 | 0.9987 | 1.0620 | |
| HCC1187 | TNBC | Basal A | Celecoxib | COX2 | COX | 10518.136 | uM | inf | inf | 0.9091 | 0.9091 | 0.0000 | 0.0220 | 0.1805 | 1.2490 |