Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10999.143 | 0.0215 | -0.9987 | 0.5216 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12379.143 | 0.9875 | 0.9448 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12379.143 | 1.0317 | 1.1437 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12379.143 | 1.0144 | 1.0648 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12379.143 | 1.0342 | 1.1553 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12379.143 | 1.0157 | 1.0706 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12379.143 | 0.9667 | 0.8549 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12379.143 | 0.8365 | 0.3443 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12379.143 | 0.4468 | -0.6672 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12379.143 | 0.0233 | -0.9995 | 0.4493 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10938.143 | 0.9364 | 0.8749 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10938.143 | 0.9052 | 0.8134 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10938.143 | 0.6925 | 0.3937 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10938.143 | 0.8861 | 0.7758 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10938.143 | 0.8808 | 0.7653 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10938.143 | 0.6599 | 0.3292 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10938.143 | 0.8281 | 0.6615 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10938.143 | 0.3919 | -0.2036 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10938.143 | 0.1123 | -0.7670 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12333.143 | 0.9482 | 0.8373 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12333.143 | 0.9555 | 0.8598 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12333.143 | 1.0088 | 1.0283 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12333.143 | 1.0011 | 1.0036 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12333.143 | 0.9222 | 0.7574 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12333.143 | 0.9204 | 0.7519 | 0.6265 |