Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | PD184352 | MEK | MAPK | 1.33 | uM | 12365.155 | 0.8323 | 0.8334 | 2.1113 | |
| MCF12A | NM | Basal B | PD184352 | MEK | MAPK | 6.67 | uM | 12365.155 | 0.8089 | 0.8089 | 2.1113 | |
| MCF12A | NM | Basal B | PD184352 | MEK | MAPK | 6.67 | uM | 12365.155 | 0.8089 | 0.8089 | 2.1113 | |
| MCF12A | NM | Basal B | PD184352 | MEK | MAPK | 33.3 | uM | 12365.155 | 0.3327 | 0.1876 | 2.1113 | |
| MCF12A | NM | Basal B | PD184352 | MEK | MAPK | 33.3 | uM | 12365.155 | 0.3327 | 0.1876 | 2.1113 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10997.155 | 1.0169 | 1.0257 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10997.155 | 1.0169 | 1.0257 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 10997.155 | 1.0419 | 1.0633 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 10997.155 | 1.0419 | 1.0633 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.00213 | uM | 10997.155 | 1.0261 | 1.0396 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.00213 | uM | 10997.155 | 1.0261 | 1.0396 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0107 | uM | 10997.155 | 1.0018 | 1.0028 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0107 | uM | 10997.155 | 1.0018 | 1.0028 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 10997.155 | 1.0516 | 1.0780 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 10997.155 | 1.0516 | 1.0780 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.267 | uM | 10997.155 | 1.0302 | 1.0457 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 0.267 | uM | 10997.155 | 1.0302 | 1.0457 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 10997.155 | 1.0789 | 1.1188 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 10997.155 | 1.0789 | 1.1188 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 10997.155 | 0.9683 | 0.9516 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 10997.155 | 0.9683 | 0.9516 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 10997.155 | 1.0962 | 1.1446 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 10997.155 | 1.0962 | 1.1446 | 1.3159 | |
| MDA-MB-134-VI | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10998.155 | 0.8993 | 0.7842 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10998.155 | 0.8993 | 0.7842 | 0.9302 |