Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7517.066 | 0.9298 | 0.8929 | 1.3218 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7517.066 | 0.7196 | 0.5592 | 1.3218 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7518.066 | 0.9663 | 0.9558 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7518.066 | 0.9917 | 0.9892 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7518.066 | 0.9532 | 0.9384 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7518.066 | 0.9995 | 0.9993 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7518.066 | 1.0337 | 1.0438 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7518.066 | 0.9422 | 0.9238 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7518.066 | 0.9871 | 0.9831 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7518.066 | 0.9863 | 0.9821 | 1.5326 | |
| MDA-MB-453 | TNBC | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7518.066 | 0.3777 | 0.0596 | 1.5326 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7523.066 | 0.9672 | 0.9196 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.000427 | uM | 7523.066 | 0.9595 | 0.9008 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.00213 | uM | 7523.066 | 0.9745 | 0.9374 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0107 | uM | 7523.066 | 0.9833 | 0.9590 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0533 | uM | 7523.066 | 0.9460 | 0.8681 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.267 | uM | 7523.066 | 0.9525 | 0.8839 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 1.33 | uM | 7523.066 | 0.9571 | 0.8949 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 6.67 | uM | 7523.066 | 0.8852 | 0.7213 | 0.8127 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 33.3 | uM | 7523.066 | 0.7919 | 0.5009 | 0.8127 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7526.066 | 0.9790 | 0.9736 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7526.066 | 0.9857 | 0.9820 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7526.066 | 1.0080 | 1.0100 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7526.066 | 1.0201 | 1.0251 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7526.066 | 1.0198 | 1.0248 | 1.5937 |