Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5909.066 | 1.1259 | 1.0794 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 5909.066 | 1.0912 | 1.0581 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 5909.066 | 1.0603 | 1.0388 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 5909.066 | 1.0286 | 1.0186 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 5909.066 | 1.0941 | 1.0599 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 5909.066 | 1.0155 | 1.0101 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 5909.066 | 1.0602 | 1.0388 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 5909.066 | 1.0134 | 1.0088 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 5909.066 | 0.9502 | 0.9667 | 3.0464 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5910.066 | 1.1087 | 1.0682 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 5910.066 | 1.0904 | 1.0570 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 5910.066 | 1.1162 | 1.0727 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 5910.066 | 1.1269 | 1.0792 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 5910.066 | 1.0258 | 1.0166 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 5910.066 | 1.1705 | 1.1050 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 5910.066 | 1.0719 | 1.0456 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 5910.066 | 1.0554 | 1.0353 | 3.0773 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 5910.066 | 1.0316 | 1.0203 | 3.0773 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5911.066 | 1.0135 | 1.0218 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 5911.066 | 0.8967 | 0.8318 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 5911.066 | 0.8653 | 0.7800 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 5911.066 | 0.9615 | 0.9377 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 5911.066 | 0.9513 | 0.9212 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 5911.066 | 0.8995 | 0.8364 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 5911.066 | 0.9540 | 0.9255 | 1.2414 |