Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 11851.154 | 1.0289 | 1.0489 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 11851.154 | 1.0736 | 1.1244 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 11851.154 | 0.7778 | 0.6153 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 11851.154 | 0.0244 | -0.9149 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 11851.154 | 0.0050 | -0.9780 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 11851.154 | 0.0104 | -0.9587 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 11851.154 | 0.0111 | -0.9563 | 1.1765 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10875.154 | 1.0226 | 1.0632 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.000427 | uM | 10875.154 | 1.0811 | 1.2300 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.00213 | uM | 10875.154 | 1.0169 | 1.0473 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0107 | uM | 10875.154 | 1.1246 | 1.3563 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0533 | uM | 10875.154 | 1.0186 | 1.0521 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.267 | uM | 10875.154 | 0.6711 | 0.1462 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 1.33 | uM | 10875.154 | 0.1549 | -0.8520 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 6.67 | uM | 10875.154 | 0.0337 | -0.9824 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 33.3 | uM | 10875.154 | 0.0161 | -0.9937 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12428.167 | 0.9397 | 0.8812 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.000427 | uM | 12428.167 | 0.9820 | 0.9646 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.00213 | uM | 12428.167 | 1.0207 | 1.0407 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0107 | uM | 12428.167 | 0.9957 | 0.9915 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.0533 | uM | 12428.167 | 0.9777 | 0.9560 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 0.267 | uM | 12428.167 | 0.7581 | 0.5231 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 1.33 | uM | 12428.167 | 0.3726 | -0.2425 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 6.67 | uM | 12428.167 | 0.1064 | -0.7792 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 33.3 | uM | 12428.167 | 0.0600 | -0.8743 | 1.0169 |