Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | GW843682X | PLK | PLK | 33.3 | uM | 10642.139 | 0.9984 | 0.9954 | 0.7017 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 0.0000853 | uM | 10643.139 | 1.0719 | 1.2292 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 0.000427 | uM | 10643.139 | 1.0734 | 1.2340 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 0.00213 | uM | 10643.139 | 1.0263 | 1.0829 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 0.0107 | uM | 10643.139 | 1.0361 | 1.1138 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 0.0533 | uM | 10643.139 | 1.0169 | 1.0531 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 0.267 | uM | 10643.139 | 1.1001 | 1.3212 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 1.33 | uM | 10643.139 | 1.0637 | 1.2027 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 6.67 | uM | 10643.139 | 1.0826 | 1.2639 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 33.3 | uM | 10643.139 | 1.1093 | 1.3520 | 0.6402 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 0.0000853 | uM | 10644.139 | 1.0386 | 1.1285 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 0.000427 | uM | 10644.139 | 0.9586 | 0.8655 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 0.00213 | uM | 10644.139 | 0.9572 | 0.8612 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 0.0107 | uM | 10644.139 | 0.9379 | 0.7998 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 0.0533 | uM | 10644.139 | 1.0005 | 1.0017 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 0.267 | uM | 10644.139 | 0.9530 | 0.8478 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 1.33 | uM | 10644.139 | 1.0156 | 1.0517 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 6.67 | uM | 10644.139 | 0.9811 | 0.9380 | 0.6077 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 33.3 | uM | 10644.139 | 0.9395 | 0.8049 | 0.6077 | |
| SUM159PT | TNBC | Basal B | GW843682X | PLK | PLK | 0.0000853 | uM | 10520.139 | 1.0338 | 1.0183 | 3.6491 | |
| SUM159PT | TNBC | Basal B | GW843682X | PLK | PLK | 0.000427 | uM | 10520.139 | 0.8628 | 0.9207 | 3.6491 | |
| SUM159PT | TNBC | Basal B | GW843682X | PLK | PLK | 0.00213 | uM | 10520.139 | 0.8007 | 0.8818 | 3.6491 | |
| SUM159PT | TNBC | Basal B | GW843682X | PLK | PLK | 0.0107 | uM | 10520.139 | 1.0300 | 1.0163 | 3.6491 | |
| SUM159PT | TNBC | Basal B | GW843682X | PLK | PLK | 0.0533 | uM | 10520.139 | 1.0173 | 1.0094 | 3.6491 | |
| SUM159PT | TNBC | Basal B | GW843682X | PLK | PLK | 0.267 | uM | 10520.139 | 0.7519 | 0.8497 | 3.6491 |