Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7893.001 | 0.4246 | 0.3790 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7893.001 | 0.0047 | -0.8047 | 2.3044 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7894.001 | 1.0574 | 1.1509 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7894.001 | 0.9199 | 0.7938 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7894.001 | 0.9982 | 0.9952 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7894.001 | 1.0196 | 1.0512 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7894.001 | 1.0444 | 1.1165 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7894.001 | 0.9897 | 0.9733 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7894.001 | 0.8484 | 0.6146 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7894.001 | 0.8066 | 0.5118 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7894.001 | 0.0073 | -0.9967 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7896.001 | 1.0384 | 1.0643 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7896.001 | 1.0347 | 1.0582 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7896.001 | 0.9984 | 0.9973 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7896.001 | 0.9999 | 0.9998 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7896.001 | 1.0260 | 1.0435 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7896.001 | 1.0037 | 1.0062 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7896.001 | 0.9326 | 0.8862 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7896.001 | 0.8049 | 0.6669 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7896.001 | 0.0068 | -0.9698 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9648.001 | 1.0326 | 1.1047 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9648.001 | 0.9735 | 0.9163 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9648.001 | 0.9994 | 0.9980 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9648.001 | 0.9531 | 0.8528 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9648.001 | 1.0286 | 1.0919 | 0.6289 |