Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9047.011 | 0.3855 | -0.5603 | 0.6293 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9047.011 | 0.2904 | -0.7197 | 0.6293 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.0185 | uM | 9095.119 | 0.7207 | 0.5311 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.0924 | uM | 9095.119 | 0.6861 | 0.4709 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.462 | uM | 9095.119 | 0.7217 | 0.5330 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 2.31 | uM | 9095.119 | 0.6589 | 0.4232 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 11.5 | uM | 9095.119 | 0.6037 | 0.3253 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 57.7 | uM | 9095.119 | 0.5657 | 0.2568 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 289 | uM | 9095.119 | 0.5857 | 0.2930 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 1440 | uM | 9095.119 | 0.4981 | 0.1330 | 1.2263 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 7220 | uM | 9095.119 | 0.2171 | -0.4244 | 1.2263 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9118.011 | 1.0396 | 1.0750 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9118.011 | 1.0023 | 1.0044 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9118.011 | 0.8439 | 0.7025 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9118.011 | 0.6625 | 0.3532 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9118.011 | 0.6608 | 0.3499 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9118.011 | 0.6225 | 0.2755 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9118.011 | 0.5897 | 0.2117 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9118.011 | 0.5527 | 0.1394 | 1.0538 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9118.011 | 0.5509 | 0.1359 | 1.0538 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7793.011 | 0.9937 | 0.9889 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7793.011 | 0.9393 | 0.8936 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7793.011 | 0.8597 | 0.7528 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7793.011 | 0.2085 | -0.4910 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7793.011 | 0.1340 | -0.6541 | 1.1456 |