Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7531.088 | 0.9689 | 0.9811 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7531.088 | 1.0981 | 1.0572 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7531.088 | 1.1478 | 1.0848 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7531.088 | 0.6348 | 0.7440 | 3.3184 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7553.088 | 0.9977 | 0.9956 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7553.088 | 0.9739 | 0.9508 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7553.088 | 1.0054 | 1.0101 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7553.088 | 0.9909 | 0.9828 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7553.088 | 0.9985 | 0.9972 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7553.088 | 0.9296 | 0.8670 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7553.088 | 0.9858 | 0.9732 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7553.088 | 0.9851 | 0.9719 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7553.088 | 0.8799 | 0.7728 | 1.0607 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0000853 | uM | 10581.139 | 0.9839 | 0.9719 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 0.000427 | uM | 10581.139 | 0.9220 | 0.8635 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 0.00213 | uM | 10581.139 | 0.9260 | 0.8705 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0107 | uM | 10581.139 | 0.9358 | 0.8877 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0533 | uM | 10581.139 | 0.9725 | 0.9520 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 0.267 | uM | 10581.139 | 0.8969 | 0.8192 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 1.33 | uM | 10581.139 | 0.9934 | 0.9886 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 6.67 | uM | 10581.139 | 0.8909 | 0.8086 | 1.1488 | |
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 33.3 | uM | 10581.139 | 0.9081 | 0.8390 | 1.1488 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 0.0000853 | uM | 10473.139 | 1.0129 | 1.0213 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 0.000427 | uM | 10473.139 | 0.9373 | 0.8954 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 0.00213 | uM | 10473.139 | 0.9600 | 0.9333 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 0.0107 | uM | 10473.139 | 0.9836 | 0.9727 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 0.0533 | uM | 10473.139 | 1.0150 | 1.0249 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 0.267 | uM | 10473.139 | 0.9724 | 0.9540 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 1.33 | uM | 10473.139 | 1.0121 | 1.0201 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 6.67 | uM | 10473.139 | 0.9857 | 0.9763 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 33.3 | uM | 10473.139 | 0.8927 | 0.8203 | 1.2054 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0000853 | uM | 10518.139 | 1.0276 | 1.0446 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 0.000427 | uM | 10518.139 | 0.9696 | 0.9507 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 0.00213 | uM | 10518.139 | 0.9522 | 0.9223 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0107 | uM | 10518.139 | 0.9764 | 0.9618 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0533 | uM | 10518.139 | 1.0037 | 1.0060 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 0.267 | uM | 10518.139 | 0.9110 | 0.8548 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 1.33 | uM | 10518.139 | 0.8706 | 0.7880 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 6.67 | uM | 10518.139 | 0.7457 | 0.5775 | 1.2366 | |
| HCC1187 | TNBC | Basal A | GW843682X | PLK | PLK | 33.3 | uM | 10518.139 | 0.5401 | 0.2153 | 1.2366 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0000853 | uM | 10577.139 | 1.0645 | 1.1402 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 0.000427 | uM | 10577.139 | 0.9832 | 0.9636 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 0.00213 | uM | 10577.139 | 0.9789 | 0.9542 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0107 | uM | 10577.139 | 1.0878 | 1.1908 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 0.0533 | uM | 10577.139 | 1.1159 | 1.2522 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 0.267 | uM | 10577.139 | 1.0196 | 1.0424 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 1.33 | uM | 10577.139 | 1.0586 | 1.1271 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 6.67 | uM | 10577.139 | 1.0620 | 1.1346 | 0.9234 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 33.3 | uM | 10577.139 | 1.0261 | 1.0566 | 0.9234 | |
| HCC38 | TNBC | Basal B | GW843682X | PLK | PLK | 0.0000853 | uM | 10578.139 | 1.0741 | 1.0890 | 1.6434 |