Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7466.088 | 1.0001 | 1.0002 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.267 | uM | 7466.088 | 0.9330 | 0.8545 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 1.33 | uM | 7466.088 | 0.9899 | 0.9781 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 6.67 | uM | 7466.088 | 0.9523 | 0.8963 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 33.3 | uM | 7466.088 | 0.8848 | 0.7503 | 0.9180 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7468.088 | 0.9703 | 0.8978 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7468.088 | 0.8813 | 0.6052 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7468.088 | 0.9522 | 0.8364 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7468.088 | 0.9558 | 0.8486 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7468.088 | 0.9705 | 0.8985 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7468.088 | 0.9033 | 0.6756 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7468.088 | 0.9430 | 0.8056 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7468.088 | 0.9636 | 0.8751 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7468.088 | 0.7908 | 0.3292 | 0.5744 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7470.088 | 1.0154 | 1.0277 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7470.088 | 0.9690 | 0.9439 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7470.088 | 0.9404 | 0.8921 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7470.088 | 1.0784 | 1.1411 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7470.088 | 1.0106 | 1.0191 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.267 | uM | 7470.088 | 1.0574 | 1.1034 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 1.33 | uM | 7470.088 | 1.0075 | 1.0135 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 6.67 | uM | 7470.088 | 1.0743 | 1.1337 | 1.1071 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 33.3 | uM | 7470.088 | 1.0007 | 1.0012 | 1.1071 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7485.088 | 0.9370 | 0.9649 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7485.088 | 0.9978 | 0.9988 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7485.088 | 0.9328 | 0.9625 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7485.088 | 1.0525 | 1.0280 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7485.088 | 1.0019 | 1.0010 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7485.088 | 0.9778 | 0.9878 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7485.088 | 0.9286 | 0.9601 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7485.088 | 1.0380 | 1.0204 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7485.088 | 0.4907 | 0.6475 | 3.6725 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7490.088 | 1.0348 | 1.0271 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7490.088 | 0.9707 | 0.9767 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7490.088 | 0.9819 | 0.9857 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7490.088 | 0.9943 | 0.9955 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7490.088 | 0.9687 | 0.9751 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7490.088 | 0.9786 | 0.9830 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7490.088 | 1.0037 | 1.0029 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7490.088 | 0.9331 | 0.9462 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7490.088 | 0.6077 | 0.6441 | 2.5415 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7493.088 | 1.0162 | 1.0307 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7493.088 | 1.0434 | 1.0825 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7493.088 | 0.9874 | 0.9760 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7493.088 | 1.0353 | 1.0672 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7493.088 | 1.0227 | 1.0432 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7493.088 | 1.0287 | 1.0545 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7493.088 | 1.0287 | 1.0545 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7493.088 | 1.0845 | 1.1604 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7493.088 | 1.1339 | 1.2540 | 1.0513 |