Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10263.001 | 1.0032 | 1.0196 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10263.001 | 0.9145 | 0.5203 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10263.001 | 1.0381 | 1.2430 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10263.001 | 0.9941 | 0.9639 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10263.001 | 0.7303 | -0.2378 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10263.001 | 0.4225 | -0.8578 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10263.001 | 0.5235 | -0.7256 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10263.001 | 0.6394 | -0.4932 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10263.001 | 0.6141 | -0.5522 | 0.3258 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7853.001 | 0.9578 | 0.9461 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7853.001 | 0.9705 | 0.9625 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7853.001 | 1.0097 | 1.0123 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7853.001 | 0.9877 | 0.9844 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7853.001 | 0.8584 | 0.8155 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7853.001 | 0.2850 | -0.0975 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7853.001 | 0.2912 | -0.0850 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7853.001 | 0.2829 | -0.1016 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7853.001 | 0.2739 | -0.1199 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10056.001 | 0.9668 | 0.9267 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10056.001 | 0.9644 | 0.9214 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10056.001 | 1.0053 | 1.0117 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10056.001 | 0.9940 | 0.9869 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10056.001 | 0.8280 | 0.6235 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10056.001 | 0.4540 | -0.1641 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10056.001 | 0.4489 | -0.1744 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10056.001 | 0.4518 | -0.1684 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10056.001 | 0.4422 | -0.1880 | 0.9052 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9453.001 | 0.9488 | 0.9184 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9453.001 | 0.9901 | 0.9843 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9453.001 | 1.0066 | 1.0105 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9453.001 | 0.9830 | 0.9729 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9453.001 | 0.6143 | 0.3593 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9453.001 | 0.2644 | -0.3032 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9453.001 | 0.2477 | -0.3383 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9453.001 | 0.2478 | -0.3382 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9453.001 | 0.1833 | -0.4788 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9469.001 | 0.9693 | 0.9398 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9469.001 | 1.0374 | 1.0733 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9469.001 | 0.9924 | 0.9851 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9469.001 | 1.0278 | 1.0545 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9469.001 | 0.5884 | 0.1893 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9469.001 | 0.3563 | -0.2728 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9469.001 | 0.2939 | -0.3979 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9469.001 | 0.3033 | -0.3788 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9469.001 | 0.2177 | -0.5513 | 1.0202 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7856.001 | 1.1814 | 1.5282 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7856.001 | 1.0219 | 1.0618 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7856.001 | 1.1513 | 1.4382 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7856.001 | 0.9603 | 0.8894 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7856.001 | 0.3770 | -0.4927 | 0.7111 |