Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7920.001 | 0.6486 | 0.8129 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7920.001 | 0.6645 | 0.8229 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7920.001 | 0.4004 | 0.6250 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7920.001 | 0.0373 | -0.0516 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9844.001 | 1.0818 | 1.0678 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9844.001 | 0.9873 | 0.9892 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9844.001 | 1.0897 | 1.0742 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9844.001 | 0.9910 | 0.9923 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9844.001 | 0.7619 | 0.7822 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9844.001 | 0.7087 | 0.7283 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9844.001 | 0.6351 | 0.6499 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9844.001 | 0.3626 | 0.3008 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9844.001 | 0.0320 | -0.5353 | 2.3587 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10146.001 | 1.0146 | 1.0397 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10146.001 | 1.0380 | 1.1040 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10146.001 | 1.1113 | 1.3084 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10146.001 | 1.0937 | 1.2590 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10146.001 | 1.1409 | 1.3926 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10146.001 | 1.0067 | 1.0183 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10146.001 | 0.7222 | 0.2849 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10146.001 | 0.3083 | -0.5961 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10146.001 | 0.0104 | -0.9960 | 0.7356 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9860.001 | 0.9841 | 0.9802 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.000427 | uM | 9860.001 | 1.0357 | 1.0439 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.00213 | uM | 9860.001 | 1.0071 | 1.0088 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.0107 | uM | 9860.001 | 0.9481 | 0.9350 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.0533 | uM | 9860.001 | 0.7483 | 0.6708 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 0.267 | uM | 9860.001 | 0.6800 | 0.5744 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 1.33 | uM | 9860.001 | 0.6020 | 0.4598 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 6.67 | uM | 9860.001 | 0.3472 | 0.0375 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 33.3 | uM | 9860.001 | 0.0140 | -0.8582 | 1.6119 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9878.001 | 1.1038 | 1.1532 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9878.001 | 0.9927 | 0.9891 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9878.001 | 1.0406 | 1.0603 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9878.001 | 0.8276 | 0.7364 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9878.001 | 0.8586 | 0.7847 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9878.001 | 0.5149 | 0.2181 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9878.001 | 0.3408 | -0.1051 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9878.001 | 0.2558 | -0.2778 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9878.001 | 0.1387 | -0.5428 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9889.001 | 1.1099 | 1.1476 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9889.001 | 0.9766 | 0.9680 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9889.001 | 1.0358 | 1.0486 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9889.001 | 1.0122 | 1.0166 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9889.001 | 0.8346 | 0.7676 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9889.001 | 0.6018 | 0.4138 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9889.001 | 0.3254 | -0.0711 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9889.001 | 0.2259 | -0.2762 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9889.001 | 0.1039 | -0.5741 | 1.4638 | |
| T47D | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9897.001 | 1.0509 | 1.1993 | 0.5223 |