Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7907.001 | 0.1032 | -0.6370 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7907.001 | 0.1110 | -0.6166 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7907.001 | 0.1245 | -0.5821 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7907.001 | 0.3334 | -0.1238 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7907.001 | 0.0535 | -0.7783 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7909.001 | 1.0825 | 1.1021 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7909.001 | 0.9315 | 0.9128 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7909.001 | 1.1352 | 1.1659 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7909.001 | 0.9477 | 0.9336 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7909.001 | 0.3676 | 0.0662 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7909.001 | 0.2337 | -0.1981 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7909.001 | 0.2623 | -0.1376 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7909.001 | 0.5340 | 0.3482 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7909.001 | 0.0957 | -0.5424 | 1.5909 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9759.001 | 1.0720 | 1.1210 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9759.001 | 1.0403 | 1.0678 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9759.001 | 1.0728 | 1.1223 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9759.001 | 0.9380 | 0.8947 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9759.001 | 1.0114 | 1.0193 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9759.001 | 1.0021 | 1.0035 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9759.001 | 1.0414 | 1.0697 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9759.001 | 0.8427 | 0.7307 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9759.001 | 0.4332 | -0.0136 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9760.001 | 1.0461 | 1.0953 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9760.001 | 1.0241 | 1.0498 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9760.001 | 1.0440 | 1.0910 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9760.001 | 0.9525 | 0.9018 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9760.001 | 0.9870 | 0.9730 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9760.001 | 0.9796 | 0.9579 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9760.001 | 0.9707 | 0.9396 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9760.001 | 0.6698 | 0.3218 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9760.001 | 0.2883 | -0.4467 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10127.001 | 1.0969 | 1.2281 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10127.001 | 0.9089 | 0.7890 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10127.001 | 1.0853 | 1.2004 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10127.001 | 1.0009 | 1.0021 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10127.001 | 1.0831 | 1.1954 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10127.001 | 0.9652 | 0.9189 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10127.001 | 0.9907 | 0.9784 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10127.001 | 0.6243 | 0.1540 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10127.001 | 0.2977 | -0.5137 | 0.8568 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9777.001 | 0.9781 | 0.9396 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9777.001 | 1.3014 | 1.8801 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9777.001 | 1.0672 | 1.1885 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9777.001 | 1.2039 | 1.5859 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9777.001 | 0.9162 | 0.7717 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9777.001 | 1.2417 | 1.6989 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9777.001 | 0.8807 | 0.6774 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9777.001 | 0.5574 | -0.1095 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9777.001 | 0.0023 | -0.9996 | 0.7223 |