Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7853.001 | 0.9421 | 0.9258 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7853.001 | 0.8852 | 0.8512 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7853.001 | 0.8740 | 0.8364 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7853.001 | 0.7232 | 0.6286 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7853.001 | 0.3018 | -0.0642 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10056.001 | 1.0253 | 1.0559 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 10056.001 | 0.9902 | 0.9784 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 10056.001 | 0.9716 | 0.9374 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 10056.001 | 0.9706 | 0.9350 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 10056.001 | 0.9757 | 0.9464 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 10056.001 | 0.9660 | 0.9250 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 10056.001 | 0.9549 | 0.9005 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 10056.001 | 0.8553 | 0.6829 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 10056.001 | 0.6144 | 0.1678 | 0.9052 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9453.001 | 0.9808 | 0.9695 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9453.001 | 0.9854 | 0.9768 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9453.001 | 1.0042 | 1.0066 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9453.001 | 0.9312 | 0.8901 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9453.001 | 0.6491 | 0.4200 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9453.001 | 0.6138 | 0.3583 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9453.001 | 0.5704 | 0.2817 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9453.001 | 0.3640 | -0.1022 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9453.001 | 0.0220 | -0.9029 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9469.001 | 1.0380 | 1.0744 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9469.001 | 1.0109 | 1.0214 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9469.001 | 1.0283 | 1.0554 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9469.001 | 0.9776 | 0.9561 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9469.001 | 0.7547 | 0.5179 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9469.001 | 0.7413 | 0.4914 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9469.001 | 0.7521 | 0.5126 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9469.001 | 0.4092 | -0.1670 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9469.001 | 0.0105 | -0.9770 | 1.0202 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7856.001 | 1.1516 | 1.4393 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7856.001 | 1.0499 | 1.1417 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7856.001 | 1.1076 | 1.3091 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7856.001 | 1.0025 | 1.0072 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7856.001 | 0.7467 | 0.3262 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7856.001 | 0.7361 | 0.2999 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7856.001 | 0.7621 | 0.3649 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7856.001 | 0.6038 | -0.0162 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7856.001 | 0.3234 | -0.5911 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7857.001 | 0.9938 | 0.9894 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7857.001 | 0.9818 | 0.9688 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7857.001 | 1.0074 | 1.0125 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7857.001 | 0.9343 | 0.8873 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7857.001 | 0.7334 | 0.5352 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7857.001 | 0.6954 | 0.4671 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7857.001 | 0.5865 | 0.2687 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7857.001 | 0.4322 | -0.0222 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7857.001 | 0.0750 | -0.7804 | 1.1724 |