Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9047.001 | 0.9480 | 0.8661 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.267 | uM | 9047.001 | 0.8718 | 0.6737 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 1.33 | uM | 9047.001 | 0.8043 | 0.5074 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 6.67 | uM | 9047.001 | 0.5173 | -0.1502 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 33.3 | uM | 9047.001 | 0.3723 | -0.4457 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10002.001 | 0.9855 | 0.9465 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10002.001 | 0.9854 | 0.9458 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10002.001 | 1.0011 | 1.0042 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10002.001 | 0.9925 | 0.9723 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10002.001 | 0.9722 | 0.8978 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.267 | uM | 10002.001 | 0.9250 | 0.7299 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 1.33 | uM | 10002.001 | 0.7677 | 0.2227 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 6.67 | uM | 10002.001 | 0.6497 | -0.1037 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 33.3 | uM | 10002.001 | 0.4484 | -0.5505 | 0.5372 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9095.001 | 1.0418 | 1.0799 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9095.001 | 0.9872 | 0.9755 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9095.001 | 1.0469 | 1.0897 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9095.001 | 0.9337 | 0.8729 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9095.001 | 0.8620 | 0.7350 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 0.267 | uM | 9095.001 | 0.8102 | 0.6351 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 1.33 | uM | 9095.001 | 0.7086 | 0.4380 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 6.67 | uM | 9095.001 | 0.4422 | -0.0844 | 1.0444 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 33.3 | uM | 9095.001 | 0.1983 | -0.5752 | 1.0444 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9118.001 | 1.0899 | 1.1637 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9118.001 | 1.0101 | 1.0184 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9118.001 | 1.0483 | 1.0880 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9118.001 | 0.9534 | 0.9147 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9118.001 | 1.0430 | 1.0785 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9118.001 | 1.0278 | 1.0508 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9118.001 | 1.0415 | 1.0756 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9118.001 | 0.9113 | 0.8373 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9118.001 | 0.1046 | -0.7457 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9120.001 | 1.0688 | 1.2275 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9120.001 | 0.9859 | 0.9546 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9120.001 | 1.0433 | 1.1420 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9120.001 | 0.9920 | 0.9742 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9120.001 | 1.0021 | 1.0067 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9120.001 | 1.0382 | 1.1250 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9120.001 | 1.0972 | 1.3239 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9120.001 | 0.9264 | 0.7673 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9120.001 | 0.0233 | -0.9954 | 0.6180 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7793.001 | 1.0877 | 1.1516 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7793.001 | 1.0518 | 1.0897 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7793.001 | 1.0640 | 1.1107 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7793.001 | 0.9074 | 0.8380 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7793.001 | 0.9108 | 0.8440 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7793.001 | 0.9107 | 0.8438 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7793.001 | 0.9664 | 0.9415 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7793.001 | 0.6491 | 0.3738 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7793.001 | 0.0655 | -0.8129 | 1.1508 |