Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | GM6001 | MMP | MMP | 33.3 | uM | 7496.096 | 0.9165 | 0.8444 | 1.0771 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.0000853 | uM | 7506.096 | 0.9174 | 0.8394 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.000427 | uM | 7506.096 | 1.0059 | 1.0114 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.00213 | uM | 7506.096 | 0.9399 | 0.8832 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.0107 | uM | 7506.096 | 1.0348 | 1.0675 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.0533 | uM | 7506.096 | 0.9918 | 0.9840 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.267 | uM | 7506.096 | 1.0243 | 1.0472 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 1.33 | uM | 7506.096 | 0.9804 | 0.9619 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 6.67 | uM | 7506.096 | 0.9894 | 0.9793 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 33.3 | uM | 7506.096 | 1.0468 | 1.0907 | 1.0303 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.0000853 | uM | 7527.096 | 0.8905 | 0.8931 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.000427 | uM | 7527.096 | 0.9209 | 0.9234 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.00213 | uM | 7527.096 | 0.9131 | 0.9158 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.0107 | uM | 7527.096 | 0.9574 | 0.9592 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.0533 | uM | 7527.096 | 0.9416 | 0.9438 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 0.267 | uM | 7527.096 | 0.9754 | 0.9765 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 1.33 | uM | 7527.096 | 0.9047 | 0.9073 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 6.67 | uM | 7527.096 | 0.9186 | 0.9212 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 33.3 | uM | 7527.096 | 0.9324 | 0.9348 | 2.1119 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.0000853 | uM | 7530.096 | 0.9247 | 0.9287 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.000427 | uM | 7530.096 | 0.9688 | 0.9708 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.00213 | uM | 7530.096 | 0.9245 | 0.9285 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.0107 | uM | 7530.096 | 1.0354 | 1.0326 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.0533 | uM | 7530.096 | 0.9801 | 0.9814 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.267 | uM | 7530.096 | 0.9594 | 0.9619 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 1.33 | uM | 7530.096 | 0.9237 | 0.9277 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 6.67 | uM | 7530.096 | 0.9057 | 0.9101 | 2.1549 | |
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 33.3 | uM | 7530.096 | 0.7442 | 0.7438 | 2.1549 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.0000853 | uM | 7531.096 | 0.9355 | 0.9628 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.000427 | uM | 7531.096 | 0.8910 | 0.9360 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.00213 | uM | 7531.096 | 0.9431 | 0.9673 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.0107 | uM | 7531.096 | 0.9900 | 0.9943 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.0533 | uM | 7531.096 | 1.0924 | 1.0504 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 0.267 | uM | 7531.096 | 0.9247 | 0.9564 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 1.33 | uM | 7531.096 | 0.9017 | 0.9425 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 6.67 | uM | 7531.096 | 0.8650 | 0.9199 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 33.3 | uM | 7531.096 | 0.9086 | 0.9467 | 3.5504 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 0.0000853 | uM | 7553.096 | 0.9359 | 0.8871 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 0.000427 | uM | 7553.096 | 0.9229 | 0.8641 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 0.00213 | uM | 7553.096 | 0.9400 | 0.8944 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 0.0107 | uM | 7553.096 | 0.9599 | 0.9295 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 0.0533 | uM | 7553.096 | 0.9693 | 0.9461 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 0.267 | uM | 7553.096 | 0.9529 | 0.9171 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 1.33 | uM | 7553.096 | 0.9459 | 0.9048 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 6.67 | uM | 7553.096 | 0.9124 | 0.8456 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 33.3 | uM | 7553.096 | 0.9445 | 0.9023 | 1.1407 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9047.001 | 1.0685 | 1.1796 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9047.001 | 0.9646 | 0.9084 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9047.001 | 0.9807 | 0.9501 | 0.7701 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9047.001 | 0.9582 | 0.8921 | 0.7701 |