Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5901.084 | 0.0081 | -0.8744 | 1.7402 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5901.084 | 0.0022 | -0.9407 | 1.7402 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5902.084 | 1.0532 | 1.0781 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5902.084 | 0.9734 | 0.9606 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5902.084 | 1.0331 | 1.0487 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5902.084 | 1.0206 | 1.0303 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5902.084 | 0.9264 | 0.8901 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5902.084 | 0.7645 | 0.6400 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5902.084 | 0.0247 | -0.8704 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5902.084 | 0.0111 | -0.9280 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5902.084 | 0.0097 | -0.9350 | 1.3532 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5903.084 | 1.0198 | 1.0328 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5903.084 | 0.9772 | 0.9622 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5903.084 | 0.9712 | 0.9522 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5903.084 | 1.0377 | 1.0622 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5903.084 | 0.9671 | 0.9453 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5903.084 | 0.8284 | 0.7115 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5903.084 | 0.0175 | -0.9298 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5903.084 | 0.0091 | -0.9589 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5903.084 | 0.0047 | -0.9762 | 1.2088 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5904.085 | 1.0709 | 1.1150 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5904.085 | 0.9735 | 0.9566 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5904.085 | 1.0298 | 1.0486 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5904.085 | 1.0169 | 1.0276 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5904.085 | 1.0195 | 1.0318 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5904.085 | 0.1154 | -0.6571 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5904.085 | 0.0201 | -0.9176 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5904.085 | 0.0144 | -0.9372 | 1.2247 | |
| BT-20 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5904.085 | 0.0053 | -0.9724 | 1.2247 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5905.085 | 0.9991 | 0.9980 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5905.085 | 1.0323 | 1.0732 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5905.085 | 0.9968 | 0.9927 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5905.085 | 0.9535 | 0.8952 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5905.085 | 0.9029 | 0.7819 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5905.085 | 0.6054 | 0.1341 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5905.085 | 0.0176 | -0.9791 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5905.085 | 0.0087 | -0.9907 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5905.085 | 0.0055 | -0.9944 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5906.084 | 0.9894 | 0.9614 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5906.084 | 1.0359 | 1.1336 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5906.084 | 1.0459 | 1.1717 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5906.084 | 1.0343 | 1.1277 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5906.084 | 0.9743 | 0.9068 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5906.084 | 0.8075 | 0.3510 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5906.084 | 0.0169 | -0.9989 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5906.084 | 0.0148 | -0.9991 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5906.084 | 0.0070 | -0.9998 | 0.5452 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5908.084 | 0.9762 | 0.9037 | 0.4873 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5908.084 | 0.9500 | 0.8002 | 0.4873 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5908.084 | 0.9859 | 0.9425 | 0.4873 |