Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Perturbagen Concentration	Perturbagen Conc Unit	Biological Replicate ID	Relative Cell Count	Normalized Growth Rate Inhibition Value	Nominal Division Rate
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	0.00427	uM	7553.074	0.9345	0.8625	0.9515
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	0.0213	uM	7553.074	0.9876	0.9739	0.9515
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	0.107	uM	7553.074	0.9287	0.8503	0.9515
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	0.533	uM	7553.074	0.9153	0.8223	0.9515
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	2.67	uM	7553.074	0.6965	0.3675	0.9515
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	13.3	uM	7553.074	0.5651	0.0979	0.9515
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	66.7	uM	7553.074	0.4486	-0.1388	0.9515
ZR-75-1	HR+	Luminal	Etoposide	TOP2	TOP	333	uM	7553.074	0.3174	-0.4013	0.9515
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	0.000853	uM	7555.074	0.9094	0.8893	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	0.00427	uM	7555.074	0.9631	0.9554	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	0.0213	uM	7555.074	0.8695	0.8392	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	0.107	uM	7555.074	0.8158	0.7702	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	0.533	uM	7555.074	0.6726	0.5768	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	2.67	uM	7555.074	0.5616	0.4153	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	13.3	uM	7555.074	0.4511	0.2411	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	66.7	uM	7555.074	0.3360	0.0402	1.6682
ZR75B	HR+	Luminal	Etoposide	TOP2	TOP	333	uM	7555.074	0.2768	-0.0739	1.6682
184A1	NM	Basal	Everolimus	MTOR	MTOR	0.000171	uM	12509.164	0.8385	0.7259	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	0.000853	uM	12509.164	0.6888	0.4639	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	0.00427	uM	12509.164	0.7302	0.5372	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	0.0213	uM	12509.164	0.6638	0.4194	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	0.107	uM	12509.164	0.6689	0.4285	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	0.533	uM	12509.164	0.6509	0.3962	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	2.67	uM	12509.164	0.6319	0.3620	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	13.3	uM	12509.164	0.4491	0.0234	1.1949
184A1	NM	Basal	Everolimus	MTOR	MTOR	66.7	uM	12509.164	0.0090	-0.9610	1.1949
184B5	NM	Basal	Everolimus	MTOR	MTOR	0.000171	uM	12566.164	0.9703	0.9607	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	0.000853	uM	12566.164	0.8636	0.8157	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	0.00427	uM	12566.164	0.8398	0.7826	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	0.0213	uM	12566.164	0.7631	0.6735	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	0.107	uM	12566.164	0.7645	0.6755	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	0.533	uM	12566.164	0.7618	0.6717	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	2.67	uM	12566.164	0.7531	0.6591	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	13.3	uM	12566.164	0.5011	0.2684	1.5173
184B5	NM	Basal	Everolimus	MTOR	MTOR	66.7	uM	12566.164	0.5362	0.3262	1.5173
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	0.000171	uM	12224.164	1.0244	1.0579	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	0.000853	uM	12224.164	0.9658	0.9194	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	0.00427	uM	12224.164	1.0094	1.0224	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	0.0213	uM	12224.164	0.9852	0.9651	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	0.107	uM	12224.164	0.9692	0.9274	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	0.533	uM	12224.164	0.9124	0.7946	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	2.67	uM	12224.164	0.8986	0.7624	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	13.3	uM	12224.164	0.8530	0.6571	0.8454
600MPE	HR+	Luminal	Everolimus	MTOR	MTOR	66.7	uM	12224.164	0.6230	0.1428	0.8454
AU565	HER2amp	Luminal	Everolimus	MTOR	MTOR	0.000171	uM	10880.156	1.0702	1.0908	1.5288
AU565	HER2amp	Luminal	Everolimus	MTOR	MTOR	0.000853	uM	10880.156	0.9913	0.9886	1.5288
AU565	HER2amp	Luminal	Everolimus	MTOR	MTOR	0.00427	uM	10880.156	1.0012	1.0016	1.5288
AU565	HER2amp	Luminal	Everolimus	MTOR	MTOR	0.0213	uM	10880.156	0.8334	0.7752	1.5288
AU565	HER2amp	Luminal	Everolimus	MTOR	MTOR	0.107	uM	10880.156	0.6199	0.4628	1.5288
AU565	HER2amp	Luminal	Everolimus	MTOR	MTOR	0.533	uM	10880.156	0.5873	0.4120	1.5288

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)