Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.00427 | uM | 7467.074 | 0.9756 | 0.9607 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.0213 | uM | 7467.074 | 1.0153 | 1.0245 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.107 | uM | 7467.074 | 0.9674 | 0.9475 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.533 | uM | 7467.074 | 0.8363 | 0.7327 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 2.67 | uM | 7467.074 | 0.6415 | 0.4004 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 13.3 | uM | 7467.074 | 0.1734 | -0.5101 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 66.7 | uM | 7467.074 | 0.0549 | -0.8054 | 1.2457 | |
| HCC3153 | TNBC | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 7467.074 | 0.0496 | -0.8207 | 1.2457 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7468.074 | 0.9969 | 0.9959 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7468.074 | 0.9642 | 0.9521 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7468.074 | 0.9505 | 0.9336 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7468.074 | 0.8645 | 0.8153 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7468.074 | 0.4336 | 0.1469 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 2.67 | uM | 7468.074 | 0.1087 | -0.5432 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 13.3 | uM | 7468.074 | 0.0340 | -0.7893 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 66.7 | uM | 7468.074 | 0.0331 | -0.7930 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 333 | uM | 7468.074 | 0.0273 | -0.8181 | 1.5027 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7469.074 | 1.0516 | 1.0513 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7469.074 | 1.0472 | 1.0471 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7469.074 | 0.9800 | 0.9797 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7469.074 | 0.9175 | 0.9150 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7469.074 | 0.4390 | 0.3208 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 2.67 | uM | 7469.074 | 0.1138 | -0.3310 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 13.3 | uM | 7469.074 | 0.0523 | -0.5478 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 66.7 | uM | 7469.074 | 0.0500 | -0.5580 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 333 | uM | 7469.074 | 0.0475 | -0.5694 | 1.9843 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.000853 | uM | 7470.074 | 0.9551 | 0.9068 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.00427 | uM | 7470.074 | 0.9471 | 0.8902 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.0213 | uM | 7470.074 | 0.9640 | 0.9252 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.107 | uM | 7470.074 | 0.9304 | 0.8555 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.533 | uM | 7470.074 | 0.8538 | 0.6969 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 2.67 | uM | 7470.074 | 0.7813 | 0.5473 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 13.3 | uM | 7470.074 | 0.8014 | 0.5888 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 66.7 | uM | 7470.074 | 0.2435 | -0.5395 | 0.9618 | |
| HCC70 | TNBC | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 7470.074 | 0.0898 | -0.8368 | 0.9618 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7472.074 | 1.2066 | 1.2504 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7472.074 | 0.9179 | 0.8953 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7472.074 | 0.9737 | 0.9668 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7472.074 | 1.3528 | 1.4180 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7472.074 | 1.8344 | 1.9277 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 2.67 | uM | 7472.074 | 1.4829 | 1.5615 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 13.3 | uM | 7472.074 | 0.5026 | 0.2983 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 66.7 | uM | 7472.074 | 0.0504 | -0.6937 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 333 | uM | 7472.074 | 0.0653 | -0.6398 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7473.074 | 1.0830 | 1.0639 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7473.074 | 1.0051 | 1.0040 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7473.074 | 1.0548 | 1.0425 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7473.074 | 1.6716 | 1.4491 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7473.074 | 1.2635 | 1.1932 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 2.67 | uM | 7473.074 | 0.9667 | 0.9735 | 2.5364 |