Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Perturbagen Concentration	Perturbagen Conc Unit	Biological Replicate ID	Relative Cell Count	Normalized Growth Rate Inhibition Value	Nominal Division Rate
UACC-812	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	0.00427	uM	13078.174	0.9747	0.9195	0.6238
UACC-812	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	0.0213	uM	13078.174	0.9882	0.9624	0.6238
UACC-812	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	0.107	uM	13078.174	0.6725	0.0589	0.6238
UACC-812	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	13078.174	0.3284	-0.6644	0.6238
UACC-812	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	13078.174	0.3102	-0.6937	0.6238
UACC-812	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	13078.174	0.5448	-0.2445	0.6238
UACC-812	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	13078.174	0.5127	-0.3146	0.6238
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000171	uM	12677.174	0.9283	0.8564	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000853	uM	12677.174	1.0000	1.0000	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.00427	uM	12677.174	0.9694	0.9388	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.0213	uM	12677.174	0.9683	0.9365	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.107	uM	12677.174	0.6844	0.3683	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	12677.174	0.5178	0.0350	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	12677.174	0.9000	0.7998	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	12677.174	0.7846	0.5690	0.9992
ZR-75-1	HR+	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	12677.174	0.7122	0.4240	0.9992
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000171	uM	13595.174	0.9720	0.9697	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000853	uM	13595.174	0.9678	0.9652	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.00427	uM	13595.174	1.0300	1.0321	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.0213	uM	13595.174	1.0089	1.0095	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.107	uM	13595.174	0.7922	0.7645	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	13595.174	0.5556	0.4581	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	13595.174	0.7591	0.7245	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	13595.174	0.7796	0.7493	1.8596
ZR75B	HR+	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	13595.174	0.2783	0.0054	1.8596
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.0000256	uM	9047.002	0.9296	0.7401	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.000128	uM	9047.002	1.0589	1.2307	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.00064	uM	9047.002	0.8672	0.5241	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.0032	uM	9047.002	0.9415	0.7829	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.016	uM	9047.002	0.8236	0.3814	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.08	uM	9047.002	0.7836	0.2560	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.4	uM	9047.002	0.7860	0.2634	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	2	uM	9047.002	0.8065	0.3271	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	10	uM	9047.002	0.8104	0.3392	0.5243
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.0000256	uM	10002.002	1.0011	1.0024	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.000128	uM	10002.002	1.0033	1.0070	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.00064	uM	10002.002	1.0189	1.0398	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.0032	uM	10002.002	0.9365	0.8666	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.016	uM	10002.002	0.8470	0.6792	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.08	uM	10002.002	0.7581	0.4943	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.4	uM	10002.002	0.6623	0.2962	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	2	uM	10002.002	0.7677	0.5141	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	10	uM	10002.002	0.8835	0.7556	0.9502
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.0000256	uM	12684.002	1.1476	1.1891	1.5245
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.000128	uM	12684.002	1.0297	1.0388	1.5245
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.00064	uM	12684.002	0.9135	0.8847	1.5245
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.0032	uM	12684.002	0.8819	0.8418	1.5245
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.016	uM	12684.002	0.7231	0.6168	1.5245
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.08	uM	12684.002	0.6268	0.4722	1.5245
184A1	NM	Basal	Docetaxel	TUBB	TUBB	0.4	uM	12684.002	0.6841	0.5590	1.5245

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)