Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 13009.174 | 0.8642 | 0.8034 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 13009.174 | 0.7431 | 0.6204 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 13009.174 | 0.0121 | -0.9124 | 1.4104 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 13062.174 | 0.9704 | 0.9644 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 13062.174 | 0.9700 | 0.9639 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 13062.174 | 0.9747 | 0.9695 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 13062.174 | 0.9726 | 0.9670 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 13062.174 | 0.9737 | 0.9683 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 13062.174 | 0.9808 | 0.9768 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 13062.174 | 0.9803 | 0.9762 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 13062.174 | 0.9616 | 0.9536 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 13062.174 | 0.9608 | 0.9527 | 1.6688 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 12969.174 | 0.9563 | 0.9217 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 12969.174 | 0.9917 | 0.9852 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 12969.174 | 0.9669 | 0.9408 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 12969.174 | 0.9350 | 0.8835 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 12969.174 | 0.9208 | 0.8579 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 12969.174 | 0.7838 | 0.6088 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 12969.174 | 0.8145 | 0.6650 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 12969.174 | 0.8594 | 0.7468 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 12969.174 | 0.5309 | 0.1360 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 13570.174 | 0.9794 | 0.9216 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 13570.174 | 0.9964 | 0.9862 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 13570.174 | 0.9802 | 0.9244 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 13570.174 | 1.0142 | 1.0550 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 13570.174 | 0.8875 | 0.5895 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 13570.174 | 0.8730 | 0.5399 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 13570.174 | 0.8710 | 0.5332 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 13570.174 | 0.9413 | 0.7803 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 13570.174 | 0.9261 | 0.7255 | 0.5197 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 12720.174 | 0.9678 | 0.9335 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 12720.174 | 0.9578 | 0.9129 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 12720.174 | 0.9311 | 0.8579 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 12720.174 | 0.9831 | 0.9650 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 12720.174 | 0.7131 | 0.4108 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 12720.174 | 0.5079 | -0.0062 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 12720.174 | 0.6748 | 0.3325 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 12720.174 | 0.8171 | 0.6235 | 0.9688 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 12720.174 | 0.7676 | 0.5221 | 0.9688 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 13070.174 | 0.9966 | 0.9914 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 13070.174 | 0.9878 | 0.9696 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 13070.174 | 0.9672 | 0.9183 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 13070.174 | 0.9904 | 0.9760 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 13070.174 | 0.7735 | 0.4504 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 13070.174 | 0.6343 | 0.1317 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 13070.174 | 0.7925 | 0.4950 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 13070.174 | 0.8296 | 0.5831 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 13070.174 | 0.8018 | 0.5170 | 0.7993 | |
| UACC-812 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 13078.174 | 0.9578 | 0.8663 | 0.6238 | |
| UACC-812 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 13078.174 | 0.9829 | 0.9455 | 0.6238 |