Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Perturbagen Concentration	Perturbagen Conc Unit	Biological Replicate ID	Relative Cell Count	Normalized Growth Rate Inhibition Value	Nominal Division Rate
MDA-MB-361	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	13558.174	0.4857	-0.4369	0.5699
MDA-MB-361	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	13558.174	0.8563	0.5232	0.5699
MDA-MB-361	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	13558.174	0.8276	0.4349	0.5699
MDA-MB-361	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	13558.174	0.8401	0.4732	0.5699
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000171	uM	12959.174	0.9451	0.7871	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000853	uM	12959.174	0.9418	0.7747	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.00427	uM	12959.174	0.9630	0.8552	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.0213	uM	12959.174	0.9438	0.7821	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.107	uM	12959.174	0.9540	0.8208	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	12959.174	0.9382	0.7613	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	12959.174	0.9617	0.8502	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	12959.174	0.8335	0.3915	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	12959.174	0.5107	-0.4756	0.5020
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000171	uM	13587.174	0.9724	0.9212	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.000853	uM	13587.174	0.9714	0.9182	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.00427	uM	13587.174	0.9679	0.9082	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.0213	uM	13587.174	0.9322	0.8080	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.107	uM	13587.174	0.9687	0.9105	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	13587.174	0.9415	0.8339	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	13587.174	0.9844	0.9552	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	13587.174	0.7860	0.4148	0.6955
MDA-MB-415	HR+	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	13587.174	0.0232	-0.9911	0.6955
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.000171	uM	12964.174	0.9559	0.8889	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.000853	uM	12964.174	0.9927	0.9814	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.00427	uM	12964.174	0.9829	0.9567	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.0213	uM	12964.174	1.0083	1.0210	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.107	uM	12964.174	0.7087	0.2924	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	12964.174	0.4676	-0.2373	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	12964.174	0.7501	0.3889	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	12964.174	0.5540	-0.0544	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	12964.174	0.7526	0.3947	0.7885
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.000171	uM	13562.174	1.0182	1.0505	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.000853	uM	13562.174	0.9816	0.9491	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.00427	uM	13562.174	1.0263	1.0733	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.0213	uM	13562.174	1.0095	1.0262	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.107	uM	13562.174	0.5384	-0.1518	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	0.533	uM	13562.174	0.4369	-0.3649	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	2.67	uM	13562.174	0.7131	0.2521	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	13.3	uM	13562.174	0.6954	0.2092	0.7219
MDA-MB-453	TNBC	Luminal	Disulfiram	Proteasome	Proteasome	66.7	uM	13562.174	0.6836	0.1809	0.7219
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	0.000171	uM	12667.174	1.0245	1.0606	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	0.000853	uM	12667.174	1.0232	1.0573	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	0.00427	uM	12667.174	1.0484	1.1197	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	0.0213	uM	12667.174	1.0464	1.1146	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	0.107	uM	12667.174	0.9151	0.7932	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	0.533	uM	12667.174	0.7857	0.4866	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	2.67	uM	12667.174	0.9434	0.8615	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	13.3	uM	12667.174	0.9291	0.8270	0.8129
MX1	Unknown	Unknown	Disulfiram	Proteasome	Proteasome	66.7	uM	12667.174	0.3474	-0.4553	0.8129
SK-BR-3	HER2amp	Luminal	Disulfiram	Proteasome	Proteasome	0.000171	uM	12999.174	1.0138	1.0332	0.8315

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)