Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12269.155 | 1.2016 | 1.5184 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12269.155 | 0.7608 | 0.4191 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12269.155 | 1.2071 | 1.5328 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12269.155 | 1.2566 | 1.6637 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12269.155 | 1.0425 | 1.1072 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12269.155 | 1.0578 | 1.1461 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12269.155 | 0.3211 | -0.5192 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12269.155 | 1.1117 | 1.2842 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12269.155 | 0.7463 | 0.3852 | 0.7969 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12098.155 | 0.9431 | 0.8915 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12098.155 | 0.9443 | 0.8938 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12098.155 | 0.9386 | 0.8829 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12098.155 | 0.9644 | 0.9322 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12098.155 | 0.8767 | 0.7646 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 12098.155 | 0.7163 | 0.4556 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 12098.155 | 0.2978 | -0.3689 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 12098.155 | 0.7851 | 0.5885 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 12098.155 | 0.7920 | 0.6018 | 1.0503 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11058.155 | 0.9269 | 0.9280 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11058.155 | 1.0741 | 1.0703 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11058.155 | 1.0024 | 1.0023 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11058.155 | 1.0342 | 1.0327 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11058.155 | 0.9524 | 0.9535 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 0.267 | uM | 11058.155 | 0.5518 | 0.5007 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 1.33 | uM | 11058.155 | 0.2968 | 0.1124 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 6.67 | uM | 11058.155 | 0.4149 | 0.3078 | 2.0706 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 33.3 | uM | 11058.155 | 0.7306 | 0.7186 | 2.0706 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10695.146 | 1.0195 | 1.0274 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10695.146 | 0.9323 | 0.9036 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10695.146 | 1.0546 | 1.0764 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10695.146 | 1.0182 | 1.0256 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10695.146 | 1.0234 | 1.0329 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10695.146 | 0.9632 | 0.9478 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10695.146 | 0.8231 | 0.7434 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10695.146 | 0.8217 | 0.7413 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10695.146 | 0.8998 | 0.8565 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11852.155 | 0.9295 | 0.9061 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11852.155 | 0.9677 | 0.9573 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11852.155 | 1.0019 | 1.0025 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11852.155 | 0.9582 | 0.9446 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11852.155 | 0.8122 | 0.7441 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 11852.155 | 0.7440 | 0.6464 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 11852.155 | 0.2141 | -0.2746 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 11852.155 | 0.5898 | 0.4129 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 11852.155 | 0.7317 | 0.6284 | 1.5196 | |
| T47D | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10939.155 | 1.0033 | 1.0044 | 1.5150 | |
| T47D | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10939.155 | 1.0023 | 1.0031 | 1.5150 | |
| T47D | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10939.155 | 0.9680 | 0.9575 | 1.5150 | |
| T47D | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10939.155 | 0.9685 | 0.9582 | 1.5150 | |
| T47D | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10939.155 | 0.8862 | 0.8466 | 1.5150 |