Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.4 | uM | 7839.002 | 0.0829 | -0.5375 | 1.7009 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 2 | uM | 7839.002 | 0.0978 | -0.4902 | 1.7009 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 10 | uM | 7839.002 | 0.1174 | -0.4323 | 1.7009 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.0000256 | uM | 9386.002 | 0.9622 | 0.9472 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.000128 | uM | 9386.002 | 1.0046 | 1.0064 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.00064 | uM | 9386.002 | 0.8846 | 0.8368 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.0032 | uM | 9386.002 | 0.5268 | 0.2817 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.016 | uM | 9386.002 | 0.1657 | -0.4257 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.08 | uM | 9386.002 | 0.0675 | -0.6923 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 0.4 | uM | 9386.002 | 0.0619 | -0.7100 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 2 | uM | 9386.002 | 0.0722 | -0.6775 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 10 | uM | 9386.002 | 0.0637 | -0.7044 | 1.4405 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.0000256 | uM | 7844.002 | 0.9587 | 0.8563 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.000128 | uM | 7844.002 | 0.9452 | 0.8103 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.00064 | uM | 7844.002 | 0.9438 | 0.8055 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.0032 | uM | 7844.002 | 0.9130 | 0.7027 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.016 | uM | 7844.002 | 0.6931 | 0.0456 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.08 | uM | 7844.002 | 0.5375 | -0.3331 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.4 | uM | 7844.002 | 0.5898 | -0.2141 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 2 | uM | 7844.002 | 0.4917 | -0.4304 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10 | uM | 7844.002 | 0.4556 | -0.5023 | 0.5653 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 0.0000256 | uM | 7848.002 | 0.9557 | 0.8442 | 0.5588 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 0.000128 | uM | 7848.002 | 0.9284 | 0.7511 | 0.5588 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 0.00064 | uM | 7848.002 | 0.9329 | 0.7663 | 0.5588 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 0.0032 | uM | 7848.002 | 0.8358 | 0.4507 | 0.5588 |