Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7909.13 | 0.0212 | -0.8399 | 1.5270 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 9760.131 | 1.0922 | 1.1868 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 9760.131 | 1.0221 | 1.0447 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 9760.131 | 1.0456 | 1.0924 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 9760.131 | 1.0840 | 1.1701 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 9760.131 | 0.9821 | 0.9637 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9760.131 | 0.7896 | 0.5745 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9760.131 | 0.1509 | -0.7052 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9760.131 | 0.0639 | -0.8765 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9760.131 | 0.0374 | -0.9282 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00128 | uM | 10127.049 | 0.9789 | 0.9333 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0064 | uM | 10127.049 | 1.0035 | 1.0112 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.032 | uM | 10127.049 | 0.9753 | 0.9220 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.16 | uM | 10127.049 | 1.0590 | 1.1908 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.8 | uM | 10127.049 | 1.0667 | 1.2160 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 4 | uM | 10127.049 | 1.0826 | 1.2687 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 20 | uM | 10127.049 | 1.0839 | 1.2732 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 100 | uM | 10127.049 | 0.9196 | 0.7506 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 500 | uM | 10127.049 | 0.8194 | 0.4574 | 0.6294 | |
| SUM102PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00128 | uM | 9777.049 | 1.2092 | 1.7098 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0064 | uM | 9777.049 | 0.9669 | 0.8952 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.032 | uM | 9777.049 | 0.9451 | 0.8273 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.16 | uM | 9777.049 | 0.9968 | 0.9897 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.8 | uM | 9777.049 | 0.9758 | 0.9231 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 4 | uM | 9777.049 | 1.0872 | 1.2862 | 0.6254 |