Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12949.177 | 1.0665 | 1.0740 | 1.7727 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12949.177 | 1.0637 | 1.0709 | 1.7727 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12949.177 | 0.0115 | -0.8391 | 1.7727 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12949.177 | 0.0148 | -0.8141 | 1.7727 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12949.177 | 0.0059 | -0.8898 | 1.7727 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12949.177 | 0.0138 | -0.8211 | 1.7727 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12949.177 | 0.0028 | -0.9278 | 1.7727 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12657.177 | 0.9794 | 0.9555 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12657.177 | 0.9824 | 0.9620 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12657.177 | 0.9973 | 0.9941 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12657.177 | 1.0085 | 1.0184 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12657.177 | 0.9839 | 0.9653 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12657.177 | 0.8388 | 0.6541 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12657.177 | 0.0168 | -0.9758 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12657.177 | 0.0202 | -0.9705 | 0.9257 | |
| MCF7 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12657.177 | 0.0095 | -0.9869 | 0.9257 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12662.177 | 0.9659 | 0.9597 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12662.177 | 0.9320 | 0.9191 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12662.177 | 0.9694 | 0.9639 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12662.177 | 0.9781 | 0.9743 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12662.177 | 0.9525 | 0.9437 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12662.177 | 0.8023 | 0.7579 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12662.177 | 0.0103 | -0.8630 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12662.177 | 0.0129 | -0.8437 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12662.177 | 0.0074 | -0.8870 | 1.7065 |