Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 0.24 | uM | 7537.065 | 0.9775 | 0.9758 | 1.8673 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 1.2 | uM | 7537.065 | 0.9873 | 0.9864 | 1.8673 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 6 | uM | 7537.065 | 0.8234 | 0.8024 | 1.8673 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 30 | uM | 7537.065 | 1.1389 | 1.1443 | 1.8673 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 150 | uM | 7537.065 | 0.6375 | 0.5715 | 1.8673 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 750 | uM | 7537.065 | 0.1367 | -0.3109 | 1.8673 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 3750 | uM | 7537.065 | 0.0381 | -0.6525 | 1.8673 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 18700 | uM | 7537.065 | 0.0188 | -0.7621 | 1.8673 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7539.065 | 0.8732 | 0.8168 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7539.065 | 0.8816 | 0.8291 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7539.065 | 0.9486 | 0.9265 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7539.065 | 0.9167 | 0.8804 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7539.065 | 0.8294 | 0.7516 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7539.065 | 0.3067 | -0.1346 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7539.065 | 0.0525 | -0.7524 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7539.065 | 0.0118 | -0.9140 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7539.065 | 0.0072 | -0.9392 | 1.4108 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7541.065 | 0.9843 | 0.9770 | 1.3660 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7541.065 | 1.0229 | 1.0335 | 1.3660 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7541.065 | 0.9941 | 0.9914 | 1.3660 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7541.065 | 0.7410 | 0.6059 | 1.3660 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7541.065 | 0.6443 | 0.4497 | 1.3660 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7541.065 | 0.2215 | -0.3366 | 1.3660 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7541.065 | 0.0814 | -0.6812 | 1.3660 | |
| SUM52PE | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7541.065 | 0.0280 | -0.8539 | 1.3660 |