Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM149PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7530.065 | 0.4153 | 0.3007 | 2.0424 | |
| SUM149PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7530.065 | 0.0454 | -0.5601 | 2.0424 | |
| SUM149PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7530.065 | 0.0084 | -0.8078 | 2.0424 | |
| SUM149PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7530.065 | 0.0042 | -0.8622 | 2.0424 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7531.065 | 0.9542 | 0.9730 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7531.065 | 1.0431 | 1.0247 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7531.065 | 1.0283 | 1.0163 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7531.065 | 1.0311 | 1.0179 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7531.065 | 0.8425 | 0.9030 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7531.065 | 0.4477 | 0.5840 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7531.065 | 0.1141 | 0.0653 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7531.065 | 0.0072 | -0.5230 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7531.065 | 0.0156 | -0.4015 | 3.4461 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7532.065 | 0.9819 | 0.9442 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7532.065 | 1.0036 | 1.0113 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7532.065 | 1.0061 | 1.0191 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7532.065 | 0.9286 | 0.7830 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7532.065 | 0.8676 | 0.6050 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7532.065 | 0.6040 | -0.0845 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7532.065 | 0.2714 | -0.7349 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7532.065 | 0.0680 | -0.9689 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7532.065 | 0.0173 | -0.9963 | 0.6453 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7533.065 | 0.9607 | 0.9262 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7533.065 | 0.9769 | 0.9567 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7533.065 | 0.9802 | 0.9629 | 1.0679 |