Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7526.065 | 0.9323 | 0.9121 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7526.065 | 0.9049 | 0.8758 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7526.065 | 0.9233 | 0.9002 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7526.065 | 0.7619 | 0.6797 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7526.065 | 0.7542 | 0.6689 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7526.065 | 0.1417 | -0.4293 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7526.065 | 0.0153 | -0.8632 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7526.065 | 0.0207 | -0.8337 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7526.065 | 0.0171 | -0.8530 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7527.065 | 0.8994 | 0.8882 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7527.065 | 0.9508 | 0.9459 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7527.065 | 0.9280 | 0.9206 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7527.065 | 0.9192 | 0.9107 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7527.065 | 0.8437 | 0.8238 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7527.065 | 0.2158 | -0.1297 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7527.065 | 0.0163 | -0.7861 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7527.065 | 0.0166 | -0.7837 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7527.065 | 0.0158 | -0.7896 | 1.8429 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7528.065 | 0.9613 | 0.9304 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7528.065 | 0.9660 | 0.9388 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7528.065 | 0.9509 | 0.9116 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7528.065 | 0.9663 | 0.9394 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7528.065 | 0.9558 | 0.9203 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7528.065 | 0.6506 | 0.3591 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7528.065 | 0.4348 | -0.0537 | 1.1128 |