Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12333.143 | 0.8783 | 0.6258 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12333.143 | 0.5487 | -0.2327 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12333.143 | 0.0253 | -0.9943 | 0.6265 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12414.143 | 1.0324 | 1.0544 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12414.143 | 0.9114 | 0.8500 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12414.143 | 0.9305 | 0.8826 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12414.143 | 0.9316 | 0.8843 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12414.143 | 1.0340 | 1.0571 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12414.143 | 0.9566 | 0.9268 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12414.143 | 0.7415 | 0.5554 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12414.143 | 0.2431 | -0.3907 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12414.143 | 0.0234 | -0.9149 | 1.1898 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10644.143 | 0.9663 | 0.8927 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.192 | uM | 10644.143 | 0.9027 | 0.6965 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.96 | uM | 10644.143 | 0.9592 | 0.8704 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 4.8 | uM | 10644.143 | 0.9069 | 0.7093 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 24 | uM | 10644.143 | 0.9347 | 0.7944 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 120 | uM | 10644.143 | 0.9437 | 0.8222 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 600 | uM | 10644.143 | 0.7252 | 0.1933 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 3000 | uM | 10644.143 | 0.2039 | -0.8448 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 15000 | uM | 10644.143 | 0.0111 | -0.9986 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10874.143 | 1.0056 | 1.0146 | 0.7639 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.192 | uM | 10874.143 | 0.9692 | 0.9197 | 0.7639 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 0.96 | uM | 10874.143 | 1.0266 | 1.0699 | 0.7639 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 4.8 | uM | 10874.143 | 1.0483 | 1.1274 | 0.7639 |