Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Olomoucine II | CDK1 | CDK | 133 | uM | 12254.147 | 0.0521 | -0.7461 | 1.4316 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 10817.147 | 1.0017 | 1.0022 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 10817.147 | 0.9850 | 0.9800 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 10817.147 | 0.9667 | 0.9554 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 10817.147 | 0.9755 | 0.9673 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.213 | uM | 10817.147 | 1.0528 | 1.0696 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 1.07 | uM | 10817.147 | 0.9983 | 0.9977 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 5.33 | uM | 10817.147 | 0.7724 | 0.6844 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 26.7 | uM | 10817.147 | 0.2182 | -0.2731 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 133 | uM | 10817.147 | 0.2221 | -0.2644 | 1.5041 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12365.147 | 1.1842 | 1.1928 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12365.147 | 1.3060 | 1.3128 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12365.147 | 1.0602 | 1.0647 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12365.147 | 1.0587 | 1.0631 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12365.147 | 0.9066 | 0.8961 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12365.147 | 1.4013 | 1.4031 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12365.147 | 0.9393 | 0.9330 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12365.147 | 0.0661 | -0.5439 | 1.8376 | |
| MCF12A | NM | Basal B | Olomoucine II | CDK1 | CDK | 133 | uM | 12365.147 | 0.0622 | -0.5590 | 1.8376 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 10997.147 | 0.9596 | 0.9411 | 1.3792 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 10997.147 | 0.9486 | 0.9249 | 1.3792 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 10997.147 | 1.0214 | 1.0310 | 1.3792 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 10997.147 | 0.9935 | 0.9906 | 1.3792 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 10997.147 | 0.9341 | 0.9036 | 1.3792 | |
| MCF7 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 10997.147 | 0.9709 | 0.9576 | 1.3792 |