Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Nilotinib | ABL | nRTK | 1.6 | uM | 12414.17 | 1.0301 | 1.0498 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Nilotinib | ABL | nRTK | 8 | uM | 12414.17 | 1.0124 | 1.0206 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Nilotinib | ABL | nRTK | 40 | uM | 12414.17 | 1.0398 | 1.0657 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Nilotinib | ABL | nRTK | 200 | uM | 12414.17 | 1.0142 | 1.0236 | 1.2052 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.000512 | uM | 10644.145 | 1.0578 | 1.2792 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.00256 | uM | 10644.145 | 0.9294 | 0.6871 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.0128 | uM | 10644.145 | 0.9901 | 0.9541 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.064 | uM | 10644.145 | 1.0161 | 1.0757 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.32 | uM | 10644.145 | 1.1034 | 1.5143 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 1.6 | uM | 10644.145 | 0.9901 | 0.9541 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 8 | uM | 10644.145 | 0.5849 | -0.4253 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 40 | uM | 10644.145 | 0.5169 | -0.5688 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 200 | uM | 10644.145 | 0.5931 | -0.4065 | 0.4300 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.000512 | uM | 10874.145 | 0.9857 | 0.9663 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.00256 | uM | 10874.145 | 0.9803 | 0.9537 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.0128 | uM | 10874.145 | 1.0337 | 1.0795 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.064 | uM | 10874.145 | 0.9773 | 0.9468 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 0.32 | uM | 10874.145 | 1.0012 | 1.0028 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 1.6 | uM | 10874.145 | 1.0257 | 1.0605 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 8 | uM | 10874.145 | 0.9931 | 0.9839 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 40 | uM | 10874.145 | 1.0314 | 1.0741 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 200 | uM | 10874.145 | 1.0359 | 1.0847 | 0.8505 | |
| SK-BR-3 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.000512 | uM | 11851.145 | 0.9666 | 0.9548 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.00256 | uM | 11851.145 | 0.9484 | 0.9300 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.0128 | uM | 11851.145 | 0.9649 | 0.9525 | 1.4873 |