Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7523.084 | 0.5886 | 0.1149 | 0.9069 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 333 | uM | 7523.084 | 0.5791 | 0.0951 | 0.9069 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7526.084 | 0.9696 | 0.9662 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7526.084 | 0.9330 | 0.9248 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7526.084 | 0.8336 | 0.8089 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7526.084 | 0.7833 | 0.7477 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7526.084 | 0.5235 | 0.3992 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7526.084 | 0.5484 | 0.4356 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7526.084 | 0.5564 | 0.4470 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7526.084 | 0.4871 | 0.3446 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7526.084 | 0.4276 | 0.2513 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7527.085 | 1.0271 | 1.0278 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7527.085 | 0.9984 | 0.9983 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7527.085 | 0.8694 | 0.8608 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7527.085 | 0.8793 | 0.8717 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7527.085 | 0.6521 | 0.6043 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7527.085 | 0.6200 | 0.5631 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7527.085 | 0.6163 | 0.5582 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7527.085 | 0.5515 | 0.4715 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7527.085 | 0.5618 | 0.4856 | 1.9392 | |
| SUM1315MO2 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7528.084 | 1.0084 | 1.0164 | 1.0247 | |
| SUM1315MO2 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7528.084 | 0.9799 | 0.9608 | 1.0247 | |
| SUM1315MO2 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7528.084 | 0.9512 | 0.9047 | 1.0247 | |
| SUM1315MO2 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7528.084 | 1.0210 | 1.0410 | 1.0247 | |
| SUM1315MO2 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7528.084 | 0.9824 | 0.9657 | 1.0247 |