Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 5904.085 | 1.1798 | 1.2890 | 1.2247 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5905.085 | 0.9933 | 0.9848 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5905.085 | 0.9901 | 0.9777 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5905.085 | 0.9824 | 0.9603 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5905.085 | 0.9400 | 0.8648 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5905.085 | 0.9704 | 0.9332 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5905.085 | 1.0164 | 1.0371 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5905.085 | 0.9837 | 0.9631 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5905.085 | 0.9410 | 0.8672 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5905.085 | 0.9469 | 0.8803 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5906.084 | 1.0326 | 1.1214 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5906.084 | 1.0396 | 1.1477 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5906.084 | 1.0144 | 1.0532 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5906.084 | 0.9935 | 0.9763 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5906.084 | 1.0397 | 1.1482 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5906.084 | 1.0174 | 1.0642 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5906.084 | 1.0863 | 1.3278 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5906.084 | 1.0347 | 1.1291 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5906.084 | 0.9328 | 0.7604 | 0.5452 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5908.084 | 0.9515 | 0.8061 | 0.4873 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5908.084 | 0.9661 | 0.8634 | 0.4873 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5908.084 | 0.9607 | 0.8420 | 0.4873 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5908.084 | 0.9817 | 0.9257 | 0.4873 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5908.084 | 0.8800 | 0.5385 | 0.4873 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5908.084 | 0.8980 | 0.6039 | 0.4873 |