Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12000.167 | 0.9794 | 0.9428 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12000.167 | 0.8513 | 0.5985 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12000.167 | 0.6211 | 0.0307 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12000.167 | 0.5296 | -0.1743 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12000.167 | 0.3252 | -0.5812 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12000.167 | 0.0094 | -0.9970 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12084.154 | 0.9792 | 0.9679 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12084.154 | 0.9619 | 0.9409 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12084.154 | 0.9613 | 0.9400 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12084.154 | 0.9677 | 0.9499 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12084.154 | 0.8123 | 0.7037 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12084.154 | 0.5824 | 0.3181 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12084.154 | 0.4358 | 0.0537 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12084.154 | 0.2544 | -0.3043 | 1.2963 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12084.154 | 0.0017 | -0.9852 | 1.2963 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12001.167 | 0.8983 | 0.6328 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12001.167 | 0.8946 | 0.6202 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12001.167 | 0.9348 | 0.7606 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12001.167 | 0.9420 | 0.7864 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12001.167 | 0.8671 | 0.5273 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12001.167 | 0.9511 | 0.8189 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12001.167 | 0.7867 | 0.2705 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12001.167 | 0.5787 | -0.2893 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12001.167 | 0.0602 | -0.9902 | 0.5287 | |
| HCC1428 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10693.154 | 0.9902 | 0.9774 | 0.8696 |