Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5896.098 | 1.0347 | 1.0430 | 1.6038 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5896.098 | 0.9601 | 0.9499 | 1.6038 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5896.098 | 0.9260 | 0.9063 | 1.6038 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5896.098 | 0.8132 | 0.7581 | 1.6038 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5896.098 | 0.7105 | 0.6161 | 1.6038 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5896.098 | 0.6320 | 0.5024 | 1.6038 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5899.098 | 0.9528 | 0.9142 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5899.098 | 0.9261 | 0.8653 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5899.098 | 0.9679 | 0.9416 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5899.098 | 0.9421 | 0.8945 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5899.098 | 0.9273 | 0.8675 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5899.098 | 0.9113 | 0.8381 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5899.098 | 0.8873 | 0.7943 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5899.098 | 0.8490 | 0.7237 | 1.1012 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5899.098 | 0.8831 | 0.7865 | 1.1012 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5900.098 | 1.0252 | 1.0218 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5900.098 | 1.0349 | 1.0302 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5900.098 | 1.0372 | 1.0321 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5900.098 | 1.0843 | 1.0718 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5900.098 | 0.9840 | 0.9860 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5900.098 | 0.8011 | 0.8157 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5900.098 | 0.4252 | 0.3775 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5900.098 | 0.2712 | 0.1323 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5900.098 | 0.2384 | 0.0705 | 2.2937 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5901.098 | 1.0200 | 1.0222 | 1.8013 |