Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 12365.166 | 1.0241 | 1.0253 | 1.8961 | |
| MCF12A | NM | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 12365.166 | 0.9845 | 0.9836 | 1.8961 | |
| MCF12A | NM | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 12365.166 | 0.9707 | 0.9689 | 1.8961 | |
| MCF12A | NM | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 12365.166 | 0.8410 | 0.8255 | 1.8961 | |
| MCF12A | NM | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 12365.166 | 0.4059 | 0.2431 | 1.8961 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10997.149 | 1.0103 | 1.0164 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10997.149 | 1.1021 | 1.1603 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10997.149 | 1.0157 | 1.0248 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10997.149 | 1.0348 | 1.0550 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10997.149 | 0.9692 | 0.9510 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10997.149 | 1.0054 | 1.0086 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10997.149 | 0.9361 | 0.8980 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10997.149 | 0.9788 | 0.9662 | 1.2614 | |
| MCF7 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10997.149 | 0.8670 | 0.7861 | 1.2614 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10519.137 | 0.9652 | 0.9353 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10519.137 | 0.9363 | 0.8814 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10519.137 | 0.9725 | 0.9489 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10519.137 | 0.9653 | 0.9356 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10519.137 | 1.0191 | 1.0354 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10519.137 | 0.9859 | 0.9739 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10519.137 | 0.9669 | 0.9385 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10519.137 | 0.9462 | 0.8999 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10519.137 | 0.8472 | 0.7146 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10998.149 | 0.9798 | 0.9480 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10998.149 | 0.9467 | 0.8633 | 0.7732 |