Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10997.151 | 0.9690 | 0.9529 | 1.3229 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10997.151 | 0.7889 | 0.6718 | 1.3229 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10997.151 | 0.8040 | 0.6959 | 1.3229 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10519.139 | 0.9225 | 0.8477 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10519.139 | 1.0102 | 1.0200 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10519.139 | 0.9382 | 0.8784 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10519.139 | 0.9535 | 0.9085 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10519.139 | 0.9766 | 0.9540 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10519.139 | 1.0177 | 1.0347 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10519.139 | 0.9395 | 0.8810 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10519.139 | 0.8684 | 0.7411 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10519.139 | 0.8506 | 0.7060 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10998.151 | 0.9799 | 0.9428 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10998.151 | 0.9648 | 0.9001 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10998.151 | 1.0109 | 1.0314 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10998.151 | 1.0049 | 1.0139 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10998.151 | 1.0119 | 1.0341 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10998.151 | 1.0130 | 1.0373 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10998.151 | 1.0310 | 1.0894 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10998.151 | 0.8379 | 0.5525 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10998.151 | 0.9165 | 0.7653 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12206.157 | 1.0084 | 1.0173 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12206.157 | 0.9262 | 0.8491 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12206.157 | 0.9762 | 0.9513 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12206.157 | 0.9591 | 0.9164 | 0.9766 |