Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9878.001 | 0.3159 | -0.1545 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9878.001 | 0.3007 | -0.1850 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9878.001 | 0.1811 | -0.4420 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9889.001 | 1.0647 | 1.0875 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9889.001 | 0.9649 | 0.9517 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9889.001 | 1.0535 | 1.0724 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9889.001 | 1.0041 | 1.0056 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9889.001 | 0.2773 | -0.1673 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9889.001 | 0.2506 | -0.2230 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9889.001 | 0.3096 | -0.1022 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9889.001 | 0.3445 | -0.0343 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9889.001 | 0.2541 | -0.2156 | 1.4638 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9897.001 | 1.0310 | 1.1205 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9897.001 | 0.9413 | 0.7814 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9897.001 | 1.0324 | 1.1259 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9897.001 | 1.0381 | 1.1486 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9897.001 | 0.8139 | 0.3485 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9897.001 | 0.5605 | -0.3399 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9897.001 | 0.6460 | -0.1338 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9897.001 | 0.6934 | -0.0078 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9897.001 | 0.4754 | -0.5184 | 0.5223 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7926.001 | 1.0429 | 1.1100 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7926.001 | 1.0240 | 1.0614 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7926.001 | 1.1359 | 1.3524 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7926.001 | 0.9537 | 0.8828 | 0.7852 |