Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7812.001 | 1.1048 | 1.2083 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7812.001 | 0.9733 | 0.9469 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7812.001 | 0.4548 | -0.0862 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7812.001 | 0.0853 | -0.8270 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7812.001 | 0.0794 | -0.8388 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7812.001 | 0.0953 | -0.8067 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7812.001 | 0.0985 | -0.8002 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9244.001 | 1.1115 | 1.4307 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9244.001 | 0.9188 | 0.7108 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9244.001 | 1.1148 | 1.4440 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9244.001 | 1.0006 | 1.0021 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9244.001 | 0.0572 | -0.9898 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9244.001 | 0.0396 | -0.9948 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9244.001 | 0.0343 | -0.9960 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9244.001 | 0.0369 | -0.9955 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9244.001 | 0.0740 | -0.9836 | 0.5421 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7813.001 | 1.2015 | 1.5685 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7813.001 | 0.7585 | 0.3722 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7813.001 | 1.1346 | 1.3755 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7813.001 | 1.1855 | 1.5220 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7813.001 | 0.6988 | 0.2272 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7813.001 | 0.4056 | -0.4152 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7813.001 | 0.3088 | -0.5967 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7813.001 | 0.3903 | -0.4451 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7813.001 | 0.2259 | -0.7366 | 0.7338 |