Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9972.011 | 1.1856 | 1.3955 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9972.011 | 1.2896 | 1.6190 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9972.011 | 0.7385 | 0.4503 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9972.011 | 0.6766 | 0.3218 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9972.011 | 0.7017 | 0.3738 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9972.011 | 0.6436 | 0.2534 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9972.011 | 0.6427 | 0.2516 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9972.011 | 0.6315 | 0.2284 | 0.9432 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9997.011 | 1.0937 | 1.1772 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9997.011 | 1.0014 | 1.0027 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9997.011 | 1.0901 | 1.1705 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9997.011 | 0.6553 | 0.3399 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9997.011 | 0.7716 | 0.5642 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9997.011 | 0.7434 | 0.5101 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9997.011 | 0.7455 | 0.5141 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9997.011 | 0.7039 | 0.4338 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9997.011 | 0.6932 | 0.4132 | 1.0551 | |
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12509.169 | 0.9566 | 0.9420 | 1.5064 | ||
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 0.000853 | uM | 12509.169 | 0.9515 | 0.9351 | 1.5064 | ||
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 0.00427 | uM | 12509.169 | 0.9791 | 0.9722 | 1.5064 | ||
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12509.169 | 0.8644 | 0.8155 | 1.5064 | ||
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12509.169 | 0.9872 | 0.9830 | 1.5064 | ||
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12509.169 | 0.9547 | 0.9394 | 1.5064 | ||
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 2.67 | uM | 12509.169 | 0.9833 | 0.9777 | 1.5064 | ||
| 184A1 | NM | Basal | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12509.169 | 0.9455 | 0.9269 | 1.5064 |