Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7931.016 | 0.7754 | 0.6483 | 1.3152 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7932.016 | 1.0221 | 1.0689 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7932.016 | 1.1749 | 1.5681 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7932.016 | 0.9980 | 0.9938 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7932.016 | 1.0648 | 1.2045 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7932.016 | 1.0926 | 1.2944 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7932.016 | 1.0784 | 1.2485 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7932.016 | 0.9776 | 0.9308 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7932.016 | 1.0815 | 1.2583 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7932.016 | 0.7543 | 0.2913 | 0.6446 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9972.019 | 1.0125 | 1.0235 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9972.019 | 1.0062 | 1.0115 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9972.019 | 0.9817 | 0.9656 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9972.019 | 1.0298 | 1.0559 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9972.019 | 1.0020 | 1.0038 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 9972.019 | 1.0089 | 1.0168 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 9972.019 | 0.9422 | 0.8914 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 9972.019 | 0.9908 | 0.9827 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 9972.019 | 0.2960 | -0.3622 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9997.024 | 1.1073 | 1.2216 | 0.9704 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9997.024 | 0.9763 | 0.9512 | 0.9704 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9997.024 | 1.0214 | 1.0442 | 0.9704 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9997.024 | 0.8336 | 0.6580 | 0.9704 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9997.024 | 1.0232 | 1.0478 | 0.9704 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 9997.024 | 1.0529 | 1.1092 | 0.9704 |