Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 10753.154 | 1.0844 | 1.1154 | 1.4444 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 10753.154 | 1.0430 | 1.0592 | 1.4444 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.267 | uM | 10753.154 | 1.0545 | 1.0748 | 1.4444 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 1.33 | uM | 10753.154 | 1.0517 | 1.0711 | 1.4444 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 10753.154 | 1.0117 | 1.0162 | 1.4444 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 10753.154 | 1.0609 | 1.0835 | 1.4444 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.000171 | uM | 12000.167 | 0.9241 | 0.7920 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.000853 | uM | 12000.167 | 0.9441 | 0.8463 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.00427 | uM | 12000.167 | 0.9772 | 0.9369 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0213 | uM | 12000.167 | 0.9202 | 0.7814 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.107 | uM | 12000.167 | 0.9647 | 0.9025 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.533 | uM | 12000.167 | 0.9424 | 0.8414 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 2.67 | uM | 12000.167 | 0.9568 | 0.8808 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 13.3 | uM | 12000.167 | 0.9202 | 0.7814 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 66.7 | uM | 12000.167 | 0.9453 | 0.8494 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 12084.154 | 0.8822 | 0.8157 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.000427 | uM | 12084.154 | 0.9602 | 0.9382 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.00213 | uM | 12084.154 | 0.8816 | 0.8147 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 12084.154 | 0.8504 | 0.7650 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 12084.154 | 0.9521 | 0.9256 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.267 | uM | 12084.154 | 0.9371 | 0.9022 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 1.33 | uM | 12084.154 | 0.8909 | 0.8294 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 12084.154 | 0.9457 | 0.9157 | 1.2963 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 12084.154 | 0.8545 | 0.7715 | 1.2963 | |
| HCC1419 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.000171 | uM | 12001.167 | 0.9083 | 0.6672 | 0.5287 |