Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7490.085 | 0.0080 | -0.6925 | 2.5778 | |
| MCF12A | NM | Basal B | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7490.085 | 0.0087 | -0.6822 | 2.5778 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7492.084 | 1.0308 | 1.0413 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7492.084 | 1.0285 | 1.0383 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7492.084 | 0.9954 | 0.9939 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7492.084 | 0.9926 | 0.9900 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7492.084 | 0.8563 | 0.8016 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7492.084 | 0.5890 | 0.4003 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7492.084 | 0.0112 | -0.9028 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7492.084 | 0.0121 | -0.8977 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7492.084 | 0.0096 | -0.9127 | 1.4850 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7493.085 | 1.0777 | 1.1082 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7493.085 | 1.0067 | 1.0094 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7493.085 | 1.0174 | 1.0245 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7493.085 | 0.9714 | 0.9595 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7493.085 | 0.9172 | 0.8819 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7493.085 | 0.6013 | 0.3980 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7493.085 | 0.0122 | -0.9100 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7493.085 | 0.0112 | -0.9153 | 1.4204 | |
| MCF7 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7493.085 | 0.0082 | -0.9319 | 1.4204 | |
| MDA-MB-134-VI | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7494.084 | 0.7721 | 0.5549 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7494.084 | 0.9685 | 0.9386 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7494.084 | 0.9755 | 0.9522 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7494.084 | 0.9949 | 0.9900 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7494.084 | 0.9402 | 0.8836 | 1.0275 |