LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MCF 10A Fedratinib
1.11
uM
LJP5
 72
hr
 513 7786 10362 0.7517 0.8723
MCF 10A Fedratinib
3.33
uM
LJP5
 72
hr
 513 1665 10362 0.1607 0.3117
MCF 10A Fedratinib
10
uM
LJP5
 72
hr
 513 570 10362 0.0550 0.0244
MCF 10A Trametinib
0.04
uM
LJP5
 72
hr
 513 675 10362 0.0651 0.0649
MCF 10A Trametinib
0.12
uM
LJP5
 72
hr
 513 783 10362 0.0755 0.1021
MCF 10A Trametinib
0.37
uM
LJP5
 72
hr
 513 737 10362 0.0711 0.0868
MCF 10A Trametinib
1.11
uM
LJP5
 72
hr
 513 880 10362 0.0848 0.1292
MCF 10A Trametinib
3.33
uM
LJP5
 72
hr
 513 910 10362 0.0878 0.1410
MCF 10A Trametinib
10
uM
LJP5
 72
hr
 513 1020 10362 0.0985 0.1717
MCF 10A Omipalisib
0.04
uM
LJP6
 72
hr
 513 714 10473 0.0682 0.0784
MCF 10A Omipalisib
0.12
uM
LJP6
 72
hr
 513 607 10473 0.0580 0.0382
MCF 10A Omipalisib
0.37
uM
LJP6
 72
hr
 513 536 10473 0.0512 0.0098
MCF 10A Omipalisib
1.11
uM
LJP6
 72
hr
 513 543 10473 0.0519 0.0128
MCF 10A Omipalisib
3.33
uM
LJP6
 72
hr
 513 431 10473 0.0412 -0.0395
MCF 10A Omipalisib
10
uM
LJP6
 72
hr
 513 397 10473 0.0379 -0.0574
MCF 10A Buparlisib
0.04
uM
LJP5
 72
hr
 513 10062 10362 0.9710 0.9864
MCF 10A Buparlisib
0.12
uM
LJP5
 72
hr
 513 8404 10362 0.8110 0.9057
MCF 10A Buparlisib
0.37
uM
LJP5
 72
hr
 513 5559 10362 0.5359 0.7291
MCF 10A Buparlisib
1.11
uM
LJP5
 72
hr
 513 1357 10362 0.1309 0.2500
MCF 10A Buparlisib
3.33
uM
LJP5
 72
hr
 513 386 10362 0.0372 -0.0664
MCF 10A Buparlisib
10
uM
LJP5
 72
hr
 513 331 10362 0.0320 -0.0963
MCF 10A XL147
0.04
uM
LJP5
 72
hr
 513 10693 10362 1.0321 1.0145
MCF 10A XL147
0.12
uM
LJP5
 72
hr
 513 10166 10362 0.9807 0.9906
MCF 10A XL147
0.37
uM
LJP5
 72
hr
 513 9954 10362 0.9604 0.9814
MCF 10A XL147
1.11
uM
LJP5
 72
hr
 513 9726 10362 0.9387 0.9710