LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 8 of 15: Cell count and normalized growth rate inhibition values within biological replicate 1. - Dataset (ID:20245)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Replicate Assay Well Timepoint Timepoint Unit Total Cell Count Before Treatment Total Cell Count After Treatment Total Control Cell Count Relative Cell Count Normalized Growth Rate Inhibition Value
MCF7 BX-912
10
uM
LJP5
 2
L19
 72
hr
 1235 1241 4356 0.2849 0.0025
MCF7 BX-912
10
uM
LJP5
 3
L19
 72
hr
 1235 1370 4326 0.3167 0.0589
MCF7 Selumetinib
0.04
uM
LJP6
 1
M12
 72
hr
 1235 4292 3974 1.0800 1.0934
MCF7 Selumetinib
0.04
uM
LJP6
 2
M12
 72
hr
 1235 3482 4070 0.8555 0.8265
MCF7 Selumetinib
0.04
uM
LJP6
 3
M12
 72
hr
 1235 4186 4126 1.0145 1.0166
MCF7 Selumetinib
0.12
uM
LJP6
 1
M11
 72
hr
 1235 3711 3974 0.9338 0.9204
MCF7 Selumetinib
0.12
uM
LJP6
 2
M11
 72
hr
 1235 2788 4070 0.6850 0.6051
MCF7 Selumetinib
0.12
uM
LJP6
 3
M11
 72
hr
 1235 3082 4126 0.7469 0.6912
MCF7 Selumetinib
0.37
uM
LJP6
 1
M10
 72
hr
 1235 3181 3974 0.8004 0.7526
MCF7 Selumetinib
0.37
uM
LJP6
 2
M10
 72
hr
 1235 2543 4070 0.6248 0.5215
MCF7 Selumetinib
0.37
uM
LJP6
 3
M10
 72
hr
 1235 2913 4126 0.7060 0.6373
MCF7 Selumetinib
1.11
uM
LJP6
 1
M09
 72
hr
 1235 3115 3974 0.7838 0.7309
MCF7 Selumetinib
1.11
uM
LJP6
 2
M09
 72
hr
 1235 2443 4070 0.6002 0.4864
MCF7 Selumetinib
1.11
uM
LJP6
 3
M09
 72
hr
 1235 2942 4126 0.7130 0.6466
MCF7 Selumetinib
3.33
uM
LJP6
 1
M08
 72
hr
 1235 2698 3974 0.6789 0.5895
MCF7 Selumetinib
3.33
uM
LJP6
 2
M08
 72
hr
 1235 2652 4070 0.6515 0.5591
MCF7 Selumetinib
3.33
uM
LJP6
 3
M08
 72
hr
 1235 3115 4126 0.7549 0.7016
MCF7 Selumetinib
10
uM
LJP6
 1
M07
 72
hr
 1235 2757 3974 0.6937 0.6100
MCF7 Selumetinib
10
uM
LJP6
 2
M07
 72
hr
 1235 2466 4070 0.6058 0.4946
MCF7 Selumetinib
10
uM
LJP6
 3
M07
 72
hr
 1235 2580 4126 0.6253 0.5269
MCF7 MK2206
0.04
uM
LJP6
 1
F06
 72
hr
 1235 2598 3974 0.6537 0.5542
MCF7 MK2206
0.04
uM
LJP6
 2
F06
 72
hr
 1235 2966 4070 0.7287 0.6639
MCF7 MK2206
0.04
uM
LJP6
 3
F06
 72
hr
 1235 3001 4126 0.7273 0.6655
MCF7 MK2206
0.12
uM
LJP6
 1
F05
 72
hr
 1235 2249 3974 0.5659 0.4268
MCF7 MK2206
0.12
uM
LJP6
 2
F05
 72
hr
 1235 2435 4070 0.5982 0.4836