High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1246 | 581 | 5724 | 10893 | 64.5 | 15.39 | 236.73 | 211.09 | 47 | 52 | 56 | 60 | 63 | 66 | 70 | 75 | 83 | 0.1007 | 1097 | 0.634 | 184.57 | 34.06 | 2 | 0.0786 | 450 | 0.0087 | 5.31 | 5.104 | 0.4181 | 4403.3 | 318930 | 24700000 | 2070000000 | 0.5293 | 0.1575 | 0.0011 | 0.0000 | 0.0029 | 0.0002 | 0.0149 | 0.0025 | 0.0344 | 0.0079 | 0.0831 | 0.0249 | 0.1403 | 0.0624 | 0.1470 | 0.0543 | 0.2027 | 0.0933 | 0.3736 | 0.7545 | 0.0002 | 0.0000 | 0.0006 | 0.0000 | 0.0073 | 0.0014 | 0.0168 | 0.0048 | 0.0432 | 0.0173 | 0.0852 | 0.0464 | 0.0787 | 0.0324 | 0.1224 | 0.0582 | 0.6454 | 0.8396 | 0.0146 | 0.0251 | 0.0258 | 0.0282 | 0.0538 | 0.0219 | 0.0806 | 0.1066 | 0.1333 | 0.1818 | 0.1445 | 0.1630 | 0.1333 | 0.1348 | 0.1344 | 0.1285 | 0.2800 | 0.2100 | 0.0049 | 0.0125 | 0.0245 | 0.0623 | 0.1061 | 0.1303 | 0.1318 | 0.1477 | 0.3799 | 16 | 25 | 64 | 130 | 196 | 261 | 329 | 412 | 529 | 0.0116 | 86.41 | 6.934 | 0.2713 | 100595.0 | 54000000 | 33700000000 | 23600000000000 | 0.4576 | 0.1893 | 0.0320 | 0.0013 | 0.1436 | 0.0119 | 0.2339 | 0.0569 | 0.1831 | 0.1264 | 0.1737 | 0.1747 | 0.1260 | 0.2062 | 0.0652 | 0.1467 | 0.0332 | 0.1364 | 0.0094 | 0.1396 | 0.0005 | 0.0003 | 0.0027 | 0.0008 | 0.0034 | 0.0019 | 0.0151 | 0.0095 | 0.0589 | 0.0467 | 0.0943 | 0.0811 | 0.0861 | 0.0713 | 0.1289 | 0.1061 | 0.6100 | 0.6824 | 0.0003 | 0.0012 | 0.0025 | 0.0031 | 0.0076 | 0.0127 | 0.0227 | 0.0347 | 0.0882 | 0.1018 | 0.1372 | 0.1535 | 0.1175 | 0.1148 | 0.1447 | 0.1528 | 0.4794 | 0.4254 | 0.0017 | 0.0015 | 0.0040 | 0.0185 | 0.0733 | 0.1092 | 0.0968 | 0.1432 | 0.5521 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 465 | 733 | 7026 | 3656 | 100.6 | 30.90 | 148.26 | 167.04 | 65 | 73 | 81 | 89 | 97 | 104 | 113 | 123 | 140 | 0.1726 | 631 | 0.377 | 167.26 | 48.09 | 2 | 0.0985 | 692 | 0.0015 | 26.60 | 6.822 | 0.2400 | 11071.8 | 1330000 | 176000000 | 25200000000 | 0.4612 | 0.1922 | 0.0011 | 0.0000 | 0.0014 | 0.0002 | 0.0100 | 0.0020 | 0.0292 | 0.0062 | 0.0812 | 0.0251 | 0.1558 | 0.0583 | 0.1552 | 0.0650 | 0.1918 | 0.0938 | 0.3742 | 0.7495 | 0.0008 | 0.0000 | 0.0002 | 0.0002 | 0.0038 | 0.0018 | 0.0100 | 0.0042 | 0.0318 | 0.0143 | 0.0552 | 0.0292 | 0.0538 | 0.0280 | 0.0766 | 0.0453 | 0.7678 | 0.8770 | 0.0020 | 0.0030 | 0.0087 | 0.0210 | 0.0113 | 0.0299 | 0.0533 | 0.0629 | 0.1119 | 0.1647 | 0.1519 | 0.1467 | 0.1119 | 0.0943 | 0.1446 | 0.1287 | 0.4044 | 0.3488 | 0.0003 | 0.0038 | 0.0060 | 0.0287 | 0.0581 | 0.0975 | 0.0988 | 0.1287 | 0.5781 | 12 | 15 | 21 | 45 | 85 | 132 | 183 | 263 | 396 | 0.0560 | 25.88 | 5.095 | 0.4821 | 49874.3 | 22900000 | 12600000000 | 7790000000000 | 0.5707 | 0.1133 | 0.0493 | 0.0024 | 0.1525 | 0.0214 | 0.1771 | 0.0688 | 0.1435 | 0.1234 | 0.1525 | 0.1637 | 0.1211 | 0.1827 | 0.0785 | 0.1210 | 0.0807 | 0.1257 | 0.0448 | 0.1910 | 0.0006 | 0.0000 | 0.0019 | 0.0028 | 0.0032 | 0.0022 | 0.0158 | 0.0139 | 0.0676 | 0.0565 | 0.1098 | 0.0925 | 0.0909 | 0.0637 | 0.1199 | 0.1163 | 0.5903 | 0.6521 | 0.0026 | 0.0010 | 0.0009 | 0.0073 | 0.0097 | 0.0114 | 0.0325 | 0.0291 | 0.0958 | 0.1112 | 0.1318 | 0.1424 | 0.1019 | 0.1019 | 0.1371 | 0.1486 | 0.4877 | 0.4470 | 0.0000 | 0.0007 | 0.0037 | 0.0214 | 0.0953 | 0.1071 | 0.0960 | 0.1344 | 0.5414 | |
MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 367 | 527 | 14166 | 30978 | 166.3 | 51.48 | 150.74 | 180.13 | 108 | 123 | 136 | 147 | 158 | 171 | 186 | 207 | 241 | 0.0455 | 1410 | 1.186 | 107.56 | 39.85 | 4 | 0.0193 | 274 | 0.0029 | 11.78 | 6.212 | 0.3232 | 30318.4 | 6020000 | 1290000000 | 298000000000 | 0.4567 | 0.2012 | 0.0010 | 0.0002 | 0.0020 | 0.0003 | 0.0095 | 0.0011 | 0.0293 | 0.0063 | 0.0939 | 0.0301 | 0.1627 | 0.0648 | 0.1523 | 0.0591 | 0.1747 | 0.0901 | 0.3747 | 0.7480 | 0.0004 | 0.0000 | 0.0004 | 0.0001 | 0.0027 | 0.0002 | 0.0099 | 0.0021 | 0.0378 | 0.0155 | 0.0638 | 0.0296 | 0.0626 | 0.0267 | 0.0911 | 0.0439 | 0.7313 | 0.8820 | 0.0021 | 0.0018 | 0.0049 | 0.0083 | 0.0147 | 0.0155 | 0.0350 | 0.0596 | 0.0936 | 0.1173 | 0.1393 | 0.1757 | 0.0967 | 0.1203 | 0.1362 | 0.1471 | 0.4774 | 0.3544 | 0.0008 | 0.0034 | 0.0088 | 0.0319 | 0.0709 | 0.1074 | 0.0856 | 0.1046 | 0.5866 | 8 | 10 | 15 | 33 | 75 | 129 | 195 | 283 | 413 | 0.0651 | 14.33 | 5.012 | 0.4997 | 55169.9 | 27400000 | 16300000000 | 11100000000000 | 0.5068 | 0.1638 | 0.0376 | 0.0026 | 0.1800 | 0.0101 | 0.2471 | 0.0930 | 0.1592 | 0.1413 | 0.1404 | 0.1940 | 0.1108 | 0.1938 | 0.0625 | 0.1310 | 0.0393 | 0.1131 | 0.0232 | 0.1211 | 0.0002 | 0.0002 | 0.0005 | 0.0001 | 0.0016 | 0.0012 | 0.0097 | 0.0069 | 0.0522 | 0.0426 | 0.0886 | 0.0730 | 0.0686 | 0.0557 | 0.1054 | 0.0879 | 0.6732 | 0.7326 | 0.0004 | 0.0006 | 0.0015 | 0.0020 | 0.0027 | 0.0051 | 0.0177 | 0.0220 | 0.0740 | 0.0904 | 0.1206 | 0.1278 | 0.0882 | 0.0952 | 0.1271 | 0.1330 | 0.5678 | 0.5239 | 0.0000 | 0.0020 | 0.0028 | 0.0144 | 0.0620 | 0.1077 | 0.0815 | 0.1152 | 0.6146 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1158 | 547 | 3628 | 6182 | 70.1 | 18.21 | 293.38 | 247.61 | 48 | 56 | 61 | 65 | 68 | 73 | 77 | 84 | 93 | 0.1234 | 763 | 0.764 | 96.33 | 26.17 | 2 | 0.0714 | 259 | 0.0063 | 7.41 | 5.408 | 0.3836 | 5245.5 | 419586 | 36100000 | 3360000000 | 0.4909 | 0.1773 | 0.0023 | 0.0000 | 0.0055 | 0.0006 | 0.0137 | 0.0022 | 0.0339 | 0.0099 | 0.0870 | 0.0304 | 0.1612 | 0.0565 | 0.1658 | 0.0624 | 0.1557 | 0.1052 | 0.3750 | 0.7327 | 0.0000 | 0.0000 | 0.0003 | 0.0003 | 0.0021 | 0.0006 | 0.0086 | 0.0049 | 0.0429 | 0.0204 | 0.0689 | 0.0357 | 0.0703 | 0.0319 | 0.0998 | 0.0512 | 0.7071 | 0.8550 | 0.0014 | 0.0156 | 0.0205 | 0.0156 | 0.0533 | 0.1172 | 0.0861 | 0.1367 | 0.1516 | 0.1797 | 0.1954 | 0.1680 | 0.1175 | 0.1016 | 0.1434 | 0.0977 | 0.2309 | 0.1680 | 0.0029 | 0.0041 | 0.0140 | 0.0479 | 0.0918 | 0.1350 | 0.1227 | 0.1508 | 0.4307 | 31 | 70 | 122 | 175 | 230 | 293 | 376 | 483 | 655 | 0.0026 | 110.17 | 7.306 | 0.2160 | 147376.0 | 96400000 | 74100000000 | 63400000000000 | 0.5179 | 0.1541 | 0.0174 | 0.0019 | 0.0872 | 0.0087 | 0.1851 | 0.0367 | 0.1986 | 0.0783 | 0.1928 | 0.1522 | 0.1415 | 0.2011 | 0.0688 | 0.1609 | 0.0736 | 0.1542 | 0.0349 | 0.2059 | 0.0013 | 0.0005 | 0.0023 | 0.0022 | 0.0085 | 0.0027 | 0.0214 | 0.0121 | 0.0628 | 0.0486 | 0.0986 | 0.0955 | 0.0832 | 0.0720 | 0.1216 | 0.1055 | 0.6003 | 0.6608 | 0.0015 | 0.0037 | 0.0040 | 0.0086 | 0.0119 | 0.0165 | 0.0308 | 0.0354 | 0.0826 | 0.0886 | 0.1323 | 0.1405 | 0.0930 | 0.1069 | 0.1264 | 0.1497 | 0.5174 | 0.4502 | 0.0012 | 0.0016 | 0.0113 | 0.0311 | 0.0638 | 0.1179 | 0.0973 | 0.1179 | 0.5579 | |
MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 727 | 410 | 4323 | 18730 | 284.9 | 68.71 | 48.75 | 82.54 | 205 | 226 | 243 | 259 | 275 | 295 | 317 | 340 | 377 | 0.0526 | 985 | 0.713 | 167.73 | 44.42 | 1 | 0.1020 | 441 | 0.0010 | 43.50 | 7.099 | 0.1678 | 85895.4 | 27400000 | 9230000000 | 3280000000000 | 0.4160 | 0.2277 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0066 | 0.0000 | 0.0210 | 0.0018 | 0.0798 | 0.0225 | 0.1736 | 0.0513 | 0.1569 | 0.0548 | 0.1853 | 0.0791 | 0.3760 | 0.7905 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0029 | 0.0000 | 0.0082 | 0.0009 | 0.0360 | 0.0172 | 0.0703 | 0.0289 | 0.0670 | 0.0280 | 0.0861 | 0.0407 | 0.7289 | 0.8843 | 0.0059 | 0.0118 | 0.0071 | 0.0078 | 0.0142 | 0.0510 | 0.0673 | 0.0980 | 0.1311 | 0.1922 | 0.1865 | 0.1961 | 0.1074 | 0.1059 | 0.1287 | 0.1216 | 0.3518 | 0.2157 | 0.0021 | 0.0010 | 0.0088 | 0.0247 | 0.0809 | 0.1108 | 0.0876 | 0.1221 | 0.5621 | 6 | 8 | 9 | 11 | 13 | 18 | 32 | 65 | 143 | 0.1830 | 2.23 | 3.000 | 0.7083 | 9189.6 | 2810000 | 1040000000 | 430000000000 | 0.5119 | 0.1460 | 0.0261 | 0.0044 | 0.0782 | 0.0114 | 0.1583 | 0.0409 | 0.1676 | 0.0735 | 0.1918 | 0.1395 | 0.1629 | 0.1883 | 0.1006 | 0.1280 | 0.0726 | 0.1513 | 0.0419 | 0.2626 | 0.0010 | 0.0014 | 0.0014 | 0.0020 | 0.0028 | 0.0041 | 0.0130 | 0.0112 | 0.0434 | 0.0338 | 0.0578 | 0.0500 | 0.0580 | 0.0465 | 0.0811 | 0.0695 | 0.7414 | 0.7815 | 0.0000 | 0.0000 | 0.0018 | 0.0028 | 0.0040 | 0.0050 | 0.0143 | 0.0160 | 0.0564 | 0.0607 | 0.0804 | 0.0958 | 0.0666 | 0.0668 | 0.0927 | 0.0914 | 0.6839 | 0.6616 | 0.0000 | 0.0027 | 0.0049 | 0.0151 | 0.0457 | 0.0722 | 0.0624 | 0.0849 | 0.7122 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 944 | 643 | 10766 | 25398 | 77.7 | 26.50 | 79.35 | 104.73 | 50 | 58 | 63 | 68 | 73 | 79 | 85 | 93 | 108 | 0.0568 | 1442 | 1.039 | 62.30 | 19.70 | 12 | 0.0144 | 155 | 0.0021 | 19.33 | 6.548 | 0.2687 | 6739.6 | 660302 | 73500000 | 9260000000 | 0.4514 | 0.1914 | 0.0004 | 0.0001 | 0.0041 | 0.0004 | 0.0155 | 0.0014 | 0.0404 | 0.0069 | 0.0933 | 0.0282 | 0.1426 | 0.0518 | 0.1465 | 0.0640 | 0.1811 | 0.0814 | 0.3762 | 0.7657 | 0.0003 | 0.0000 | 0.0017 | 0.0001 | 0.0045 | 0.0006 | 0.0160 | 0.0048 | 0.0422 | 0.0180 | 0.0703 | 0.0309 | 0.0638 | 0.0353 | 0.1024 | 0.0473 | 0.6987 | 0.8630 | 0.0039 | 0.0067 | 0.0111 | 0.0183 | 0.0261 | 0.0202 | 0.0623 | 0.0577 | 0.1044 | 0.0876 | 0.1358 | 0.1107 | 0.0894 | 0.0808 | 0.1049 | 0.1078 | 0.4621 | 0.5101 | 0.0018 | 0.0078 | 0.0155 | 0.0331 | 0.0750 | 0.0992 | 0.0965 | 0.1223 | 0.5488 | 24 | 27 | 31 | 34 | 39 | 47 | 64 | 99 | 187 | 0.1253 | 4.89 | 3.514 | 0.7026 | 17262.9 | 7360000 | 4380000000 | 3170000000000 | 0.5875 | 0.1331 | 0.0281 | 0.0053 | 0.1260 | 0.0156 | 0.1868 | 0.0425 | 0.1366 | 0.0966 | 0.1545 | 0.1560 | 0.1417 | 0.1683 | 0.1034 | 0.1305 | 0.0757 | 0.1316 | 0.0472 | 0.2536 | 0.0005 | 0.0026 | 0.0029 | 0.0056 | 0.0074 | 0.0082 | 0.0218 | 0.0211 | 0.0702 | 0.0565 | 0.0928 | 0.0744 | 0.0750 | 0.0686 | 0.1091 | 0.0987 | 0.6202 | 0.6644 | 0.0015 | 0.0009 | 0.0017 | 0.0024 | 0.0077 | 0.0079 | 0.0283 | 0.0323 | 0.0924 | 0.0996 | 0.1194 | 0.1287 | 0.0811 | 0.0910 | 0.1267 | 0.1337 | 0.5411 | 0.5034 | 0.0002 | 0.0021 | 0.0070 | 0.0280 | 0.0826 | 0.1089 | 0.0754 | 0.1199 | 0.5761 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 816 | 393 | 5950 | 11342 | 117.6 | 33.32 | 249.29 | 173.91 | 81 | 90 | 98 | 105 | 112 | 120 | 129 | 141 | 162 | 0.0886 | 1005 | 0.628 | 179.79 | 48.30 | 1 | 0.0987 | 587 | 0.0027 | 14.82 | 6.257 | 0.2986 | 14935.3 | 2060000 | 307000000 | 49700000000 | 0.4437 | 0.2043 | 0.0009 | 0.0002 | 0.0033 | 0.0000 | 0.0082 | 0.0002 | 0.0331 | 0.0046 | 0.0759 | 0.0228 | 0.1588 | 0.0532 | 0.1527 | 0.0566 | 0.1907 | 0.0777 | 0.3764 | 0.7848 | 0.0005 | 0.0002 | 0.0014 | 0.0000 | 0.0036 | 0.0002 | 0.0167 | 0.0016 | 0.0351 | 0.0130 | 0.0689 | 0.0288 | 0.0680 | 0.0227 | 0.0975 | 0.0363 | 0.7084 | 0.8972 | 0.0052 | 0.0056 | 0.0070 | 0.0056 | 0.0235 | 0.0206 | 0.0506 | 0.0882 | 0.0950 | 0.1689 | 0.1578 | 0.1388 | 0.1046 | 0.1107 | 0.1290 | 0.1370 | 0.4272 | 0.3246 | 0.0020 | 0.0051 | 0.0094 | 0.0279 | 0.0822 | 0.1188 | 0.0917 | 0.1200 | 0.5429 | 40 | 81 | 128 | 176 | 225 | 279 | 333 | 394 | 483 | 0.0016 | 78.48 | 7.365 | 0.2033 | 92387.6 | 42200000 | 22200000000 | 13200000000000 | 0.4848 | 0.1839 | 0.0286 | 0.0012 | 0.1297 | 0.0127 | 0.2654 | 0.0476 | 0.1826 | 0.1174 | 0.1568 | 0.1874 | 0.1170 | 0.2093 | 0.0749 | 0.1488 | 0.0314 | 0.1305 | 0.0136 | 0.1451 | 0.0005 | 0.0000 | 0.0003 | 0.0013 | 0.0040 | 0.0026 | 0.0198 | 0.0140 | 0.0727 | 0.0554 | 0.1270 | 0.1033 | 0.1058 | 0.0836 | 0.1312 | 0.1196 | 0.5388 | 0.6202 | 0.0012 | 0.0026 | 0.0065 | 0.0077 | 0.0102 | 0.0148 | 0.0349 | 0.0586 | 0.1118 | 0.1501 | 0.1780 | 0.1978 | 0.1268 | 0.1369 | 0.1581 | 0.1553 | 0.3725 | 0.2761 | 0.0002 | 0.0031 | 0.0062 | 0.0306 | 0.0849 | 0.1491 | 0.1161 | 0.1500 | 0.4598 | |
Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 487 | 388 | 17803 | 45389 | 157.0 | 50.28 | 154.36 | 177.24 | 92 | 114 | 128 | 142 | 155 | 168 | 183 | 200 | 225 | 0.0425 | 1928 | 1.251 | 24.52 | 7.81 | 5 | 0.0033 | 58 | 0.0011 | 27.12 | 7.140 | 0.2383 | 27189.4 | 5090000 | 1010000000 | 213000000000 | 0.4282 | 0.2106 | 0.0016 | 0.0001 | 0.0027 | 0.0011 | 0.0080 | 0.0022 | 0.0288 | 0.0083 | 0.0923 | 0.0292 | 0.1552 | 0.0530 | 0.1536 | 0.0615 | 0.1813 | 0.0892 | 0.3764 | 0.7554 | 0.0006 | 0.0001 | 0.0008 | 0.0008 | 0.0020 | 0.0012 | 0.0062 | 0.0038 | 0.0238 | 0.0118 | 0.0466 | 0.0193 | 0.0520 | 0.0202 | 0.0673 | 0.0299 | 0.8006 | 0.9130 | 0.0028 | 0.0076 | 0.0051 | 0.0076 | 0.0145 | 0.0286 | 0.0373 | 0.0753 | 0.0821 | 0.1201 | 0.1345 | 0.1711 | 0.1117 | 0.1287 | 0.1381 | 0.1368 | 0.4740 | 0.3241 | 0.0009 | 0.0019 | 0.0057 | 0.0186 | 0.0505 | 0.0897 | 0.0859 | 0.1121 | 0.6346 | 13 | 18 | 26 | 47 | 81 | 128 | 193 | 278 | 407 | 0.0395 | 20.75 | 5.394 | 0.5005 | 55240.7 | 27700000 | 16900000000 | 11900000000000 | 0.4247 | 0.2143 | 0.0378 | 0.0014 | 0.1492 | 0.0110 | 0.2622 | 0.0683 | 0.1893 | 0.1171 | 0.1504 | 0.1913 | 0.1095 | 0.1978 | 0.0586 | 0.1383 | 0.0341 | 0.1296 | 0.0088 | 0.1451 | 0.0003 | 0.0002 | 0.0011 | 0.0008 | 0.0022 | 0.0018 | 0.0130 | 0.0095 | 0.0518 | 0.0406 | 0.0919 | 0.0720 | 0.0661 | 0.0535 | 0.0987 | 0.0822 | 0.6750 | 0.7394 | 0.0006 | 0.0006 | 0.0012 | 0.0024 | 0.0051 | 0.0080 | 0.0184 | 0.0254 | 0.0735 | 0.0834 | 0.1248 | 0.1314 | 0.0862 | 0.0949 | 0.1190 | 0.1284 | 0.5712 | 0.5254 | 0.0004 | 0.0015 | 0.0030 | 0.0169 | 0.0596 | 0.1071 | 0.0813 | 0.1092 | 0.6210 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 849 | 648 | 5112 | 6565 | 125.8 | 31.35 | 178.35 | 174.51 | 89 | 99 | 108 | 116 | 122 | 129 | 138 | 149 | 167 | 0.1097 | 720 | 1.162 | 109.62 | 38.12 | 1 | 0.0534 | 273 | 0.0023 | 21.62 | 6.373 | 0.2588 | 16819.2 | 2390000 | 363000000 | 58800000000 | 0.4232 | 0.2346 | 0.0006 | 0.0000 | 0.0042 | 0.0000 | 0.0130 | 0.0002 | 0.0250 | 0.0036 | 0.0815 | 0.0212 | 0.1644 | 0.0559 | 0.1624 | 0.0520 | 0.1722 | 0.0780 | 0.3765 | 0.7890 | 0.0005 | 0.0000 | 0.0007 | 0.0000 | 0.0012 | 0.0000 | 0.0055 | 0.0006 | 0.0352 | 0.0126 | 0.0852 | 0.0358 | 0.0745 | 0.0194 | 0.0985 | 0.0372 | 0.6986 | 0.8945 | 0.0022 | 0.0030 | 0.0087 | 0.0208 | 0.0282 | 0.0653 | 0.1062 | 0.1187 | 0.1593 | 0.1988 | 0.1907 | 0.1691 | 0.1192 | 0.1128 | 0.1148 | 0.0950 | 0.2709 | 0.2166 | 0.0022 | 0.0052 | 0.0108 | 0.0388 | 0.1086 | 0.1483 | 0.1198 | 0.1362 | 0.4302 | 16 | 28 | 49 | 82 | 120 | 170 | 233 | 311 | 426 | 0.0054 | 96.61 | 6.816 | 0.3013 | 62256.2 | 29200000 | 16400000000 | 10300000000000 | 0.4788 | 0.1616 | 0.0394 | 0.0012 | 0.1386 | 0.0088 | 0.2664 | 0.0649 | 0.1673 | 0.1257 | 0.1589 | 0.1784 | 0.1147 | 0.2041 | 0.0514 | 0.1509 | 0.0346 | 0.1222 | 0.0287 | 0.1439 | 0.0000 | 0.0003 | 0.0007 | 0.0000 | 0.0023 | 0.0011 | 0.0171 | 0.0077 | 0.0635 | 0.0541 | 0.1070 | 0.0913 | 0.0846 | 0.0677 | 0.1084 | 0.1006 | 0.6164 | 0.6772 | 0.0009 | 0.0000 | 0.0023 | 0.0028 | 0.0070 | 0.0083 | 0.0232 | 0.0319 | 0.0859 | 0.0979 | 0.1226 | 0.1364 | 0.0878 | 0.0974 | 0.1333 | 0.1320 | 0.5369 | 0.4934 | 0.0008 | 0.0008 | 0.0055 | 0.0169 | 0.0777 | 0.1131 | 0.0868 | 0.1190 | 0.5795 | |||
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 750 | 676 | 11146 | 21855 | 106.6 | 28.30 | 189.51 | 171.91 | 74 | 83 | 90 | 97 | 103 | 110 | 118 | 128 | 143 | 0.0573 | 1252 | 0.886 | 106.10 | 29.53 | 1 | 0.0241 | 269 | 0.0014 | 32.07 | 6.896 | 0.2173 | 12166.0 | 1490000 | 200000000 | 29600000000 | 0.4458 | 0.2114 | 0.0009 | 0.0000 | 0.0026 | 0.0003 | 0.0096 | 0.0013 | 0.0300 | 0.0038 | 0.0861 | 0.0213 | 0.1508 | 0.0508 | 0.1608 | 0.0587 | 0.1819 | 0.0839 | 0.3773 | 0.7799 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0039 | 0.0003 | 0.0101 | 0.0021 | 0.0393 | 0.0133 | 0.0634 | 0.0258 | 0.0685 | 0.0231 | 0.0980 | 0.0366 | 0.7155 | 0.8988 | 0.0018 | 0.0088 | 0.0088 | 0.0164 | 0.0226 | 0.0582 | 0.0647 | 0.1239 | 0.1317 | 0.2010 | 0.1714 | 0.1795 | 0.1183 | 0.1163 | 0.1423 | 0.1277 | 0.3383 | 0.1681 | 0.0014 | 0.0032 | 0.0116 | 0.0332 | 0.0812 | 0.1162 | 0.1018 | 0.1287 | 0.5226 | 16 | 35 | 67 | 103 | 142 | 190 | 249 | 320 | 433 | 0.0120 | 37.39 | 6.296 | 0.3650 | 65463.6 | 30100000 | 16600000000 | 10400000000000 | 0.5497 | 0.1277 | 0.0358 | 0.0017 | 0.1299 | 0.0109 | 0.2197 | 0.0768 | 0.1613 | 0.1097 | 0.1616 | 0.1610 | 0.1328 | 0.1855 | 0.0738 | 0.1385 | 0.0543 | 0.1308 | 0.0308 | 0.1851 | 0.0000 | 0.0000 | 0.0012 | 0.0012 | 0.0025 | 0.0022 | 0.0135 | 0.0090 | 0.0598 | 0.0462 | 0.1069 | 0.0836 | 0.0781 | 0.0656 | 0.1195 | 0.1003 | 0.6185 | 0.6919 | 0.0006 | 0.0002 | 0.0018 | 0.0023 | 0.0045 | 0.0088 | 0.0267 | 0.0326 | 0.0915 | 0.1031 | 0.1477 | 0.1742 | 0.1100 | 0.1208 | 0.1446 | 0.1560 | 0.4726 | 0.4020 | 0.0002 | 0.0008 | 0.0031 | 0.0184 | 0.0746 | 0.1276 | 0.0976 | 0.1359 | 0.5419 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 341 | 154 | 3660 | 2741 | 145.1 | 40.32 | 362.39 | 193.78 | 100 | 113 | 122 | 131 | 139 | 148 | 158 | 173 | 199 | 0.1423 | 390 | 0.690 | 91.44 | 18.79 | 1 | 0.0628 | 230 | 0.0017 | 31.24 | 6.666 | 0.2130 | 22685.8 | 3840000 | 708000000 | 142000000000 | 0.4590 | 0.1971 | 0.0005 | 0.0000 | 0.0014 | 0.0000 | 0.0099 | 0.0000 | 0.0292 | 0.0034 | 0.0887 | 0.0281 | 0.1651 | 0.0650 | 0.1547 | 0.0625 | 0.1731 | 0.0940 | 0.3774 | 0.7470 | 0.0004 | 0.0000 | 0.0011 | 0.0000 | 0.0018 | 0.0000 | 0.0113 | 0.0020 | 0.0389 | 0.0146 | 0.0752 | 0.0346 | 0.0724 | 0.0242 | 0.0947 | 0.0466 | 0.7043 | 0.8781 | 0.0056 | 0.0031 | 0.0042 | 0.0061 | 0.0225 | 0.0429 | 0.0591 | 0.0982 | 0.1224 | 0.1595 | 0.1758 | 0.2178 | 0.1097 | 0.1012 | 0.1280 | 0.1380 | 0.3727 | 0.2331 | 0.0000 | 0.0056 | 0.0175 | 0.0437 | 0.0936 | 0.1392 | 0.1180 | 0.1311 | 0.4513 | 105 | 176 | 244 | 302 | 359 | 408 | 457 | 521 | 616 | 0.0007 | 113.79 | 7.416 | 0.1244 | 168859.0 | 91300000 | 54900000000 | 35900000000000 | 0.5411 | 0.1415 | 0.0040 | 0.0007 | 0.0464 | 0.0056 | 0.1300 | 0.0190 | 0.1950 | 0.0556 | 0.1963 | 0.0999 | 0.1817 | 0.1955 | 0.1300 | 0.1871 | 0.0756 | 0.1906 | 0.0411 | 0.2461 | 0.0000 | 0.0000 | 0.0029 | 0.0015 | 0.0059 | 0.0049 | 0.0305 | 0.0148 | 0.0610 | 0.0473 | 0.1103 | 0.0976 | 0.1139 | 0.0867 | 0.1144 | 0.1114 | 0.5610 | 0.6358 | 0.0032 | 0.0082 | 0.0095 | 0.0148 | 0.0242 | 0.0346 | 0.0621 | 0.0824 | 0.1137 | 0.1466 | 0.1505 | 0.1928 | 0.1232 | 0.1285 | 0.1568 | 0.1450 | 0.3568 | 0.2471 | 0.0007 | 0.0015 | 0.0154 | 0.0308 | 0.0968 | 0.1357 | 0.1086 | 0.1519 | 0.4585 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 937 | 869 | 4358 | 4787 | 150.5 | 35.67 | 215.35 | 167.50 | 110 | 121 | 130 | 138 | 145 | 153 | 163 | 177 | 197 | 0.1249 | 598 | 1.001 | 107.62 | 26.02 | 1 | 0.0569 | 248 | 0.0019 | 28.98 | 6.582 | 0.2338 | 23927.0 | 4030000 | 718000000 | 136000000000 | 0.4618 | 0.1848 | 0.0007 | 0.0000 | 0.0000 | 0.0000 | 0.0054 | 0.0000 | 0.0307 | 0.0025 | 0.0928 | 0.0234 | 0.1506 | 0.0557 | 0.1593 | 0.0605 | 0.1827 | 0.0891 | 0.3778 | 0.7688 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0028 | 0.0000 | 0.0113 | 0.0009 | 0.0423 | 0.0174 | 0.0675 | 0.0300 | 0.0805 | 0.0244 | 0.1032 | 0.0449 | 0.6920 | 0.8824 | 0.0053 | 0.0070 | 0.0119 | 0.0105 | 0.0185 | 0.0281 | 0.0793 | 0.1333 | 0.1506 | 0.2702 | 0.2127 | 0.1754 | 0.1136 | 0.1053 | 0.1532 | 0.1368 | 0.2550 | 0.1333 | 0.0032 | 0.0048 | 0.0117 | 0.0472 | 0.0881 | 0.1342 | 0.1146 | 0.1363 | 0.4599 | 40 | 68 | 99 | 133 | 170 | 220 | 274 | 347 | 446 | 0.0016 | 96.66 | 7.105 | 0.2131 | 74423.1 | 33600000 | 18100000000 | 10900000000000 | 0.5058 | 0.1647 | 0.0429 | 0.0024 | 0.1767 | 0.0102 | 0.2798 | 0.0783 | 0.1951 | 0.1428 | 0.1325 | 0.2055 | 0.0994 | 0.2127 | 0.0393 | 0.1350 | 0.0172 | 0.1183 | 0.0172 | 0.0950 | 0.0008 | 0.0007 | 0.0013 | 0.0020 | 0.0029 | 0.0038 | 0.0256 | 0.0133 | 0.0797 | 0.0673 | 0.1472 | 0.1206 | 0.1065 | 0.0823 | 0.1254 | 0.1209 | 0.5107 | 0.5891 | 0.0000 | 0.0016 | 0.0051 | 0.0048 | 0.0134 | 0.0104 | 0.0535 | 0.0670 | 0.1217 | 0.1316 | 0.1637 | 0.2041 | 0.1312 | 0.1276 | 0.1548 | 0.1515 | 0.3567 | 0.3014 | 0.0010 | 0.0035 | 0.0051 | 0.0238 | 0.1190 | 0.1570 | 0.1023 | 0.1489 | 0.4392 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 202 | 300 | 6785 | 14162 | 73.6 | 17.99 | 128.75 | 204.22 | 55 | 60 | 64 | 67 | 70 | 74 | 78 | 85 | 98 | 0.0703 | 996 | 0.964 | 72.80 | 24.35 | 1 | 0.0280 | 190 | 0.0034 | 16.24 | 6.105 | 0.2850 | 5739.9 | 477688 | 42700000 | 4120000000 | 0.4408 | 0.2110 | 0.0005 | 0.0000 | 0.0039 | 0.0005 | 0.0122 | 0.0021 | 0.0270 | 0.0047 | 0.0766 | 0.0226 | 0.1354 | 0.0389 | 0.1541 | 0.0501 | 0.2125 | 0.0784 | 0.3779 | 0.8028 | 0.0002 | 0.0000 | 0.0015 | 0.0001 | 0.0044 | 0.0000 | 0.0115 | 0.0003 | 0.0412 | 0.0127 | 0.0738 | 0.0228 | 0.0842 | 0.0195 | 0.1337 | 0.0408 | 0.6495 | 0.9038 | 0.0089 | 0.0082 | 0.0124 | 0.0392 | 0.0231 | 0.0351 | 0.0738 | 0.1072 | 0.1120 | 0.1691 | 0.1431 | 0.1794 | 0.1182 | 0.1381 | 0.1476 | 0.1196 | 0.3609 | 0.2041 | 0.0051 | 0.0116 | 0.0260 | 0.0619 | 0.0952 | 0.1284 | 0.1208 | 0.1302 | 0.4208 | 12 | 14 | 16 | 19 | 29 | 64 | 131 | 219 | 365 | 0.0796 | 32.45 | 4.690 | 0.5502 | 58277.5 | 46900000 | 56200000000 | 88300000000000 | 0.5837 | 0.1324 | 0.0408 | 0.0021 | 0.1841 | 0.0191 | 0.2326 | 0.0908 | 0.1830 | 0.1300 | 0.1709 | 0.1990 | 0.1158 | 0.1879 | 0.0364 | 0.1423 | 0.0254 | 0.1147 | 0.0110 | 0.1141 | 0.0008 | 0.0004 | 0.0008 | 0.0017 | 0.0017 | 0.0017 | 0.0080 | 0.0075 | 0.0431 | 0.0368 | 0.0772 | 0.0632 | 0.0574 | 0.0462 | 0.1056 | 0.0896 | 0.7054 | 0.7529 | 0.0008 | 0.0006 | 0.0008 | 0.0020 | 0.0029 | 0.0050 | 0.0130 | 0.0190 | 0.0619 | 0.0781 | 0.1060 | 0.1085 | 0.0824 | 0.0930 | 0.1331 | 0.1355 | 0.5993 | 0.5582 | 0.0000 | 0.0009 | 0.0016 | 0.0108 | 0.0498 | 0.0912 | 0.0683 | 0.1170 | 0.6604 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1211 | 933 | 5107 | 8578 | 147.2 | 34.74 | 108.58 | 88.65 | 103 | 115 | 125 | 137 | 146 | 155 | 166 | 176 | 193 | 0.1170 | 1004 | 0.693 | 160.95 | 32.02 | 2 | 0.0770 | 393 | 0.0018 | 21.51 | 6.568 | 0.2519 | 22877.6 | 3740000 | 639000000 | 114000000000 | 0.4445 | 0.2126 | 0.0014 | 0.0000 | 0.0027 | 0.0000 | 0.0102 | 0.0013 | 0.0287 | 0.0064 | 0.0997 | 0.0227 | 0.1387 | 0.0646 | 0.1499 | 0.0612 | 0.1899 | 0.0939 | 0.3788 | 0.7501 | 0.0008 | 0.0000 | 0.0013 | 0.0000 | 0.0046 | 0.0010 | 0.0074 | 0.0038 | 0.0378 | 0.0178 | 0.0555 | 0.0427 | 0.0558 | 0.0299 | 0.0804 | 0.0465 | 0.7565 | 0.8583 | 0.0089 | 0.0213 | 0.0138 | 0.0390 | 0.0296 | 0.0496 | 0.0847 | 0.1277 | 0.1182 | 0.2163 | 0.1665 | 0.1986 | 0.1369 | 0.0957 | 0.1567 | 0.1454 | 0.2847 | 0.1064 | 0.0012 | 0.0048 | 0.0056 | 0.0306 | 0.0692 | 0.1018 | 0.1078 | 0.1301 | 0.5489 | 25 | 38 | 50 | 65 | 83 | 105 | 133 | 168 | 225 | 0.0092 | 9.19 | 5.417 | 0.4488 | 19647.3 | 5050000 | 1670000000 | 658000000000 | 0.5401 | 0.1235 | 0.0262 | 0.0039 | 0.1077 | 0.0159 | 0.2003 | 0.0478 | 0.1830 | 0.0994 | 0.1727 | 0.1452 | 0.1312 | 0.1800 | 0.0932 | 0.1462 | 0.0559 | 0.1481 | 0.0297 | 0.2135 | 0.0012 | 0.0014 | 0.0039 | 0.0039 | 0.0105 | 0.0082 | 0.0233 | 0.0227 | 0.0730 | 0.0560 | 0.1166 | 0.0957 | 0.0997 | 0.0877 | 0.1274 | 0.1094 | 0.5443 | 0.6150 | 0.0027 | 0.0059 | 0.0080 | 0.0113 | 0.0239 | 0.0231 | 0.0448 | 0.0458 | 0.0964 | 0.1241 | 0.1511 | 0.1571 | 0.1120 | 0.1108 | 0.1257 | 0.1349 | 0.4355 | 0.3870 | 0.0018 | 0.0066 | 0.0123 | 0.0361 | 0.0866 | 0.1372 | 0.1032 | 0.1351 | 0.4810 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 951 | 364 | 5225 | 12570 | 114.6 | 29.24 | 148.81 | 175.19 | 84 | 92 | 98 | 104 | 110 | 116 | 124 | 134 | 151 | 0.0699 | 879 | 0.810 | 72.24 | 18.44 | 1 | 0.0389 | 203 | 0.0030 | 17.44 | 6.162 | 0.2786 | 13983.3 | 1830000 | 261000000 | 40800000000 | 0.4284 | 0.2226 | 0.0003 | 0.0000 | 0.0009 | 0.0000 | 0.0091 | 0.0002 | 0.0324 | 0.0035 | 0.0800 | 0.0215 | 0.1378 | 0.0503 | 0.1584 | 0.0530 | 0.2021 | 0.0722 | 0.3790 | 0.7993 | 0.0002 | 0.0000 | 0.0007 | 0.0000 | 0.0024 | 0.0000 | 0.0124 | 0.0006 | 0.0398 | 0.0144 | 0.0640 | 0.0290 | 0.0688 | 0.0226 | 0.1076 | 0.0342 | 0.7040 | 0.8992 | 0.0056 | 0.0087 | 0.0111 | 0.0173 | 0.0356 | 0.0376 | 0.0934 | 0.1272 | 0.1446 | 0.1821 | 0.1758 | 0.1792 | 0.1224 | 0.1098 | 0.1313 | 0.1156 | 0.2803 | 0.2225 | 0.0027 | 0.0045 | 0.0145 | 0.0377 | 0.0921 | 0.1403 | 0.1135 | 0.1589 | 0.4358 | 11 | 15 | 26 | 46 | 79 | 124 | 182 | 256 | 391 | 0.0134 | 67.23 | 6.423 | 0.3671 | 52832.2 | 26600000 | 16100000000 | 11000000000000 | 0.5002 | 0.1902 | 0.0463 | 0.0026 | 0.1259 | 0.0198 | 0.2117 | 0.0847 | 0.1593 | 0.1067 | 0.1464 | 0.1418 | 0.1017 | 0.1687 | 0.1017 | 0.1354 | 0.0637 | 0.1313 | 0.0432 | 0.2090 | 0.0002 | 0.0000 | 0.0006 | 0.0005 | 0.0035 | 0.0017 | 0.0186 | 0.0129 | 0.0574 | 0.0525 | 0.0893 | 0.0815 | 0.0763 | 0.0603 | 0.1007 | 0.0887 | 0.6535 | 0.7020 | 0.0005 | 0.0012 | 0.0052 | 0.0030 | 0.0073 | 0.0094 | 0.0250 | 0.0301 | 0.0725 | 0.0779 | 0.1207 | 0.1181 | 0.0816 | 0.0907 | 0.1035 | 0.1026 | 0.5837 | 0.5670 | 0.0000 | 0.0011 | 0.0045 | 0.0194 | 0.0690 | 0.1067 | 0.0853 | 0.1053 | 0.6087 | |||
Hs 578T | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 474 | 145 | 2157 | 11213 | 221.6 | 78.59 | 65.05 | 137.53 | 132 | 156 | 176 | 192 | 207 | 222 | 245 | 295 | 349 | 0.0538 | 603 | 0.725 | 94.64 | 21.02 | 1 | 0.1136 | 245 | 0.0010 | 66.86 | 7.099 | 0.1610 | 55259.5 | 15300000 | 4580000000 | 1470000000000 | 0.4001 | 0.2354 | 0.0011 | 0.0000 | 0.0000 | 0.0013 | 0.0064 | 0.0032 | 0.0416 | 0.0121 | 0.0928 | 0.0490 | 0.1738 | 0.0732 | 0.1525 | 0.0803 | 0.1514 | 0.0968 | 0.3806 | 0.6841 | 0.0000 | 0.0000 | 0.0000 | 0.0005 | 0.0027 | 0.0010 | 0.0148 | 0.0073 | 0.0425 | 0.0250 | 0.0748 | 0.0374 | 0.0742 | 0.0421 | 0.0883 | 0.0525 | 0.7026 | 0.8341 | 0.0055 | 0.0028 | 0.0037 | 0.0000 | 0.0073 | 0.0085 | 0.0147 | 0.0312 | 0.0569 | 0.0708 | 0.0734 | 0.1246 | 0.0477 | 0.1161 | 0.0734 | 0.1161 | 0.7174 | 0.5297 | 0.0000 | 0.0092 | 0.0035 | 0.0403 | 0.0909 | 0.0967 | 0.0748 | 0.0748 | 0.6099 | 12 | 14 | 15 | 17 | 18 | 20 | 25 | 45 | 176 | 0.1489 | 17.64 | 3.226 | 0.6746 | 23145.6 | 15600000 | 14100000000 | 15200000000000 | 0.6928 | 0.0672 | 0.0631 | 0.0192 | 0.1329 | 0.0266 | 0.2691 | 0.0932 | 0.2060 | 0.1391 | 0.1761 | 0.1953 | 0.1030 | 0.1982 | 0.0399 | 0.1450 | 0.0100 | 0.1109 | 0.0000 | 0.0725 | 0.0000 | 0.0037 | 0.0009 | 0.0029 | 0.0023 | 0.0054 | 0.0089 | 0.0125 | 0.0455 | 0.0432 | 0.0829 | 0.0602 | 0.0590 | 0.0557 | 0.0890 | 0.0798 | 0.7113 | 0.7366 | 0.0000 | 0.0000 | 0.0005 | 0.0006 | 0.0016 | 0.0023 | 0.0104 | 0.0116 | 0.0595 | 0.0687 | 0.1075 | 0.1167 | 0.0797 | 0.0797 | 0.1151 | 0.1358 | 0.6258 | 0.5846 | 0.0000 | 0.0010 | 0.0005 | 0.0090 | 0.0562 | 0.0853 | 0.0693 | 0.1094 | 0.6692 | |
MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 961 | 737 | 4967 | 9103 | 329.4 | 79.77 | 74.56 | 85.94 | 235 | 262 | 283 | 302 | 321 | 340 | 364 | 392 | 439 | 0.0955 | 869 | 1.203 | 114.14 | 50.48 | 1 | 0.0632 | 314 | 0.0010 | 41.76 | 7.101 | 0.1685 | 114878.0 | 42400000 | 16500000000 | 6770000000000 | 0.4275 | 0.2253 | 0.0003 | 0.0000 | 0.0007 | 0.0000 | 0.0080 | 0.0002 | 0.0251 | 0.0024 | 0.0931 | 0.0218 | 0.1507 | 0.0517 | 0.1563 | 0.0579 | 0.1845 | 0.0764 | 0.3813 | 0.7896 | 0.0003 | 0.0000 | 0.0005 | 0.0000 | 0.0008 | 0.0000 | 0.0076 | 0.0006 | 0.0416 | 0.0124 | 0.0718 | 0.0304 | 0.0680 | 0.0240 | 0.1070 | 0.0391 | 0.7025 | 0.8934 | 0.0052 | 0.0061 | 0.0000 | 0.0122 | 0.0241 | 0.0396 | 0.0680 | 0.1250 | 0.1339 | 0.1860 | 0.1695 | 0.1799 | 0.1056 | 0.1128 | 0.1538 | 0.1463 | 0.3400 | 0.1921 | 0.0013 | 0.0013 | 0.0083 | 0.0420 | 0.0918 | 0.1263 | 0.0997 | 0.1228 | 0.5066 | 6 | 8 | 13 | 22 | 41 | 63 | 93 | 132 | 194 | 0.0625 | 5.33 | 4.498 | 0.5801 | 12944.9 | 3140000 | 911000000 | 296000000000 | 0.5225 | 0.1439 | 0.0229 | 0.0000 | 0.1064 | 0.0109 | 0.2273 | 0.0510 | 0.1804 | 0.1108 | 0.1752 | 0.1639 | 0.1470 | 0.1821 | 0.0792 | 0.1561 | 0.0396 | 0.1452 | 0.0219 | 0.1800 | 0.0000 | 0.0000 | 0.0005 | 0.0016 | 0.0008 | 0.0023 | 0.0124 | 0.0105 | 0.0463 | 0.0407 | 0.0816 | 0.0537 | 0.0624 | 0.0553 | 0.0945 | 0.0834 | 0.7015 | 0.7524 | 0.0000 | 0.0008 | 0.0014 | 0.0020 | 0.0056 | 0.0061 | 0.0190 | 0.0228 | 0.0669 | 0.0759 | 0.1025 | 0.1113 | 0.0817 | 0.0893 | 0.1141 | 0.1199 | 0.6088 | 0.5718 | 0.0009 | 0.0006 | 0.0019 | 0.0126 | 0.0638 | 0.0854 | 0.0780 | 0.1043 | 0.6524 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1207 | 372 | 6747 | 8059 | 84.9 | 22.08 | 226.14 | 174.03 | 59 | 67 | 72 | 77 | 82 | 87 | 94 | 102 | 115 | 0.0973 | 784 | 0.311 | 92.65 | 22.47 | 1 | 0.0539 | 364 | 0.0045 | 9.29 | 5.773 | 0.3415 | 7693.6 | 743325 | 76400000 | 8330000000 | 0.4601 | 0.1955 | 0.0008 | 0.0000 | 0.0035 | 0.0002 | 0.0171 | 0.0032 | 0.0403 | 0.0059 | 0.0875 | 0.0285 | 0.1381 | 0.0496 | 0.1482 | 0.0593 | 0.1825 | 0.0963 | 0.3819 | 0.7571 | 0.0002 | 0.0000 | 0.0006 | 0.0002 | 0.0047 | 0.0008 | 0.0110 | 0.0014 | 0.0359 | 0.0141 | 0.0685 | 0.0318 | 0.0726 | 0.0278 | 0.1047 | 0.0507 | 0.7019 | 0.8732 | 0.0043 | 0.0187 | 0.0100 | 0.0280 | 0.0278 | 0.0392 | 0.0563 | 0.1157 | 0.1069 | 0.1530 | 0.1732 | 0.1549 | 0.1354 | 0.1194 | 0.1468 | 0.1269 | 0.3393 | 0.2444 | 0.0013 | 0.0070 | 0.0152 | 0.0394 | 0.0795 | 0.1166 | 0.0994 | 0.1259 | 0.5157 | 30 | 54 | 86 | 130 | 191 | 253 | 322 | 398 | 487 | 0.0018 | 56.22 | 7.234 | 0.2526 | 81419.7 | 35200000 | 16800000000 | 8580000000000 | 0.4421 | 0.1940 | 0.0106 | 0.0013 | 0.0478 | 0.0071 | 0.1354 | 0.0260 | 0.1726 | 0.0586 | 0.2159 | 0.1525 | 0.1850 | 0.2115 | 0.1062 | 0.1406 | 0.0770 | 0.1560 | 0.0496 | 0.2464 | 0.0002 | 0.0000 | 0.0002 | 0.0011 | 0.0022 | 0.0025 | 0.0077 | 0.0053 | 0.0453 | 0.0374 | 0.0716 | 0.0706 | 0.0573 | 0.0443 | 0.0759 | 0.0693 | 0.7395 | 0.7695 | 0.0000 | 0.0000 | 0.0023 | 0.0032 | 0.0043 | 0.0056 | 0.0149 | 0.0269 | 0.0503 | 0.0622 | 0.0897 | 0.1060 | 0.0659 | 0.0779 | 0.1007 | 0.1212 | 0.6719 | 0.5969 | 0.0003 | 0.0017 | 0.0031 | 0.0136 | 0.0454 | 0.0838 | 0.0532 | 0.0830 | 0.7160 | |||
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 957 | 935 | 646 | 1422 | 460.7 | 143.67 | 222.84 | 159.64 | 216 | 331 | 421 | 468 | 496 | 523 | 546 | 575 | 619 | 0.1871 | 266 | 0.763 | 79.76 | 18.68 | 1 | 0.3266 | 211 | 0.0022 | 28.41 | 6.205 | 0.2005 | 232878.0 | 124000000 | 68500000000 | 38700000000000 | 0.3597 | 0.2776 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0032 | 0.0000 | 0.0162 | 0.0000 | 0.1262 | 0.0594 | 0.1489 | 0.0792 | 0.1392 | 0.0554 | 0.1845 | 0.1030 | 0.3819 | 0.7030 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0531 | 0.0495 | 0.0510 | 0.0531 | 0.0367 | 0.0348 | 0.0633 | 0.0531 | 0.7959 | 0.8095 | 0.0000 | 0.0244 | 0.0000 | 0.0000 | 0.0110 | 0.0000 | 0.0166 | 0.0488 | 0.1105 | 0.1707 | 0.1050 | 0.1951 | 0.0718 | 0.0976 | 0.1768 | 0.1951 | 0.5083 | 0.2683 | 0.0000 | 0.0000 | 0.0000 | 0.0101 | 0.0503 | 0.0528 | 0.0503 | 0.0729 | 0.7638 | 56 | 82 | 113 | 138 | 181 | 233 | 281 | 347 | 458 | 0.0035 | 32.63 | 6.085 | 0.3061 | 75125.3 | 32400000 | 16200000000 | 8980000000000 | 0.5133 | 0.1452 | 0.0079 | 0.0019 | 0.0791 | 0.0228 | 0.1897 | 0.0342 | 0.2095 | 0.0684 | 0.1976 | 0.1369 | 0.1581 | 0.1882 | 0.0672 | 0.1673 | 0.0751 | 0.1616 | 0.0158 | 0.2186 | 0.0000 | 0.0000 | 0.0014 | 0.0023 | 0.0014 | 0.0034 | 0.0195 | 0.0103 | 0.0627 | 0.0479 | 0.1393 | 0.1130 | 0.0669 | 0.0628 | 0.1170 | 0.0982 | 0.5919 | 0.6621 | 0.0000 | 0.0029 | 0.0000 | 0.0000 | 0.0086 | 0.0114 | 0.0409 | 0.0657 | 0.1054 | 0.1457 | 0.1699 | 0.1514 | 0.1032 | 0.1257 | 0.1527 | 0.1429 | 0.4194 | 0.3543 | 0.0000 | 0.0017 | 0.0017 | 0.0305 | 0.0746 | 0.1542 | 0.0847 | 0.1339 | 0.5186 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 872 | 575 | 6042 | 12072 | 101.1 | 29.15 | 201.53 | 223.69 | 69 | 77 | 84 | 91 | 97 | 103 | 110 | 120 | 139 | 0.0696 | 840 | 0.813 | 79.88 | 25.94 | 1 | 0.0386 | 233 | 0.0015 | 30.07 | 6.806 | 0.2198 | 11069.0 | 1320000 | 170000000 | 23900000000 | 0.4862 | 0.1865 | 0.0018 | 0.0002 | 0.0053 | 0.0006 | 0.0143 | 0.0023 | 0.0289 | 0.0069 | 0.0949 | 0.0296 | 0.1530 | 0.0590 | 0.1434 | 0.0611 | 0.1755 | 0.0846 | 0.3829 | 0.7558 | 0.0004 | 0.0000 | 0.0004 | 0.0000 | 0.0024 | 0.0005 | 0.0109 | 0.0028 | 0.0454 | 0.0160 | 0.0803 | 0.0329 | 0.0748 | 0.0325 | 0.1071 | 0.0463 | 0.6782 | 0.8690 | 0.0043 | 0.0000 | 0.0017 | 0.0123 | 0.0112 | 0.0334 | 0.0543 | 0.0598 | 0.1422 | 0.1652 | 0.1716 | 0.1845 | 0.1112 | 0.1037 | 0.1362 | 0.1564 | 0.3672 | 0.2847 | 0.0008 | 0.0053 | 0.0162 | 0.0442 | 0.0797 | 0.1330 | 0.1035 | 0.1300 | 0.4873 | 18 | 30 | 47 | 67 | 108 | 171 | 253 | 356 | 517 | 0.0128 | 34.28 | 6.003 | 0.4255 | 90647.1 | 57700000 | 45300000000 | 41800000000000 | 0.5238 | 0.1388 | 0.0299 | 0.0012 | 0.1106 | 0.0112 | 0.2542 | 0.0630 | 0.1719 | 0.1064 | 0.1356 | 0.1694 | 0.1203 | 0.2041 | 0.0759 | 0.1291 | 0.0581 | 0.1283 | 0.0436 | 0.1873 | 0.0002 | 0.0003 | 0.0012 | 0.0009 | 0.0024 | 0.0014 | 0.0120 | 0.0077 | 0.0503 | 0.0456 | 0.0918 | 0.0772 | 0.0637 | 0.0548 | 0.0892 | 0.0894 | 0.6892 | 0.7227 | 0.0008 | 0.0000 | 0.0005 | 0.0016 | 0.0040 | 0.0062 | 0.0171 | 0.0230 | 0.0656 | 0.0792 | 0.1207 | 0.1321 | 0.0874 | 0.0879 | 0.1189 | 0.1252 | 0.5850 | 0.5447 | 0.0005 | 0.0016 | 0.0021 | 0.0115 | 0.0607 | 0.1004 | 0.0736 | 0.1068 | 0.6429 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 799 | 497 | 16816 | 24748 | 122.3 | 34.96 | 236.76 | 206.30 | 82 | 94 | 102 | 110 | 118 | 126 | 136 | 149 | 168 | 0.0650 | 1609 | 1.118 | 72.20 | 25.02 | 3 | 0.0108 | 181 | 0.0021 | 18.82 | 6.539 | 0.2763 | 16190.9 | 2320000 | 358000000 | 60000000000 | 0.4389 | 0.2098 | 0.0010 | 0.0001 | 0.0025 | 0.0003 | 0.0091 | 0.0014 | 0.0328 | 0.0040 | 0.0891 | 0.0250 | 0.1521 | 0.0565 | 0.1545 | 0.0597 | 0.1758 | 0.0901 | 0.3831 | 0.7630 | 0.0004 | 0.0001 | 0.0005 | 0.0000 | 0.0026 | 0.0002 | 0.0095 | 0.0013 | 0.0356 | 0.0130 | 0.0650 | 0.0262 | 0.0618 | 0.0238 | 0.0849 | 0.0395 | 0.7396 | 0.8959 | 0.0031 | 0.0096 | 0.0075 | 0.0071 | 0.0173 | 0.0199 | 0.0537 | 0.1065 | 0.1221 | 0.1508 | 0.1553 | 0.2060 | 0.1205 | 0.1232 | 0.1477 | 0.1521 | 0.3728 | 0.2246 | 0.0013 | 0.0031 | 0.0088 | 0.0298 | 0.0749 | 0.1135 | 0.0977 | 0.1296 | 0.5413 | 21 | 45 | 86 | 134 | 187 | 246 | 312 | 397 | 532 | 0.0053 | 78.87 | 7.190 | 0.2785 | 98609.0 | 53500000 | 34300000000 | 24800000000000 | 0.5106 | 0.1669 | 0.0256 | 0.0012 | 0.1110 | 0.0083 | 0.2322 | 0.0422 | 0.1927 | 0.1005 | 0.1604 | 0.1805 | 0.1290 | 0.2104 | 0.0825 | 0.1584 | 0.0439 | 0.1366 | 0.0227 | 0.1620 | 0.0004 | 0.0002 | 0.0009 | 0.0012 | 0.0050 | 0.0019 | 0.0154 | 0.0099 | 0.0609 | 0.0492 | 0.1064 | 0.0949 | 0.0889 | 0.0752 | 0.1192 | 0.1063 | 0.6028 | 0.6612 | 0.0004 | 0.0013 | 0.0032 | 0.0039 | 0.0100 | 0.0142 | 0.0294 | 0.0412 | 0.0896 | 0.1025 | 0.1454 | 0.1529 | 0.1084 | 0.1139 | 0.1346 | 0.1366 | 0.4791 | 0.4335 | 0.0001 | 0.0020 | 0.0079 | 0.0209 | 0.0743 | 0.1266 | 0.1001 | 0.1318 | 0.5361 | |
MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 619 | 317 | 7410 | 29983 | 364.7 | 86.29 | 152.06 | 265.97 | 260 | 289 | 313 | 336 | 358 | 380 | 405 | 434 | 477 | 0.0351 | 1051 | 1.206 | 108.37 | 43.84 | 1 | 0.0379 | 281 | 0.0006 | 87.06 | 7.645 | 0.1436 | 140416.0 | 57000000 | 24300000000 | 10900000000000 | 0.4464 | 0.2073 | 0.0005 | 0.0000 | 0.0018 | 0.0001 | 0.0086 | 0.0001 | 0.0271 | 0.0018 | 0.0873 | 0.0187 | 0.1534 | 0.0482 | 0.1532 | 0.0439 | 0.1846 | 0.0654 | 0.3836 | 0.8218 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0009 | 0.0001 | 0.0081 | 0.0003 | 0.0365 | 0.0110 | 0.0711 | 0.0286 | 0.0684 | 0.0204 | 0.0949 | 0.0311 | 0.7198 | 0.9085 | 0.0050 | 0.0092 | 0.0093 | 0.0297 | 0.0328 | 0.0343 | 0.0734 | 0.0847 | 0.1290 | 0.1533 | 0.1917 | 0.2197 | 0.1226 | 0.1327 | 0.1347 | 0.1373 | 0.3015 | 0.1991 | 0.0006 | 0.0026 | 0.0110 | 0.0266 | 0.0747 | 0.1389 | 0.1155 | 0.1259 | 0.5043 | 7 | 9 | 11 | 13 | 20 | 43 | 110 | 258 | 517 | 0.1512 | 39.36 | 4.482 | 0.5817 | 93855.6 | 84800000 | 94200000000 | 120000000000000 | 0.4152 | 0.1980 | 0.0734 | 0.0021 | 0.2052 | 0.0259 | 0.2539 | 0.1687 | 0.1640 | 0.1542 | 0.1373 | 0.1932 | 0.0879 | 0.1763 | 0.0480 | 0.1107 | 0.0165 | 0.0824 | 0.0137 | 0.0866 | 0.0000 | 0.0002 | 0.0007 | 0.0005 | 0.0021 | 0.0003 | 0.0100 | 0.0059 | 0.0491 | 0.0469 | 0.0856 | 0.0756 | 0.0537 | 0.0477 | 0.0753 | 0.0702 | 0.7236 | 0.7526 | 0.0003 | 0.0001 | 0.0018 | 0.0006 | 0.0017 | 0.0025 | 0.0090 | 0.0096 | 0.0589 | 0.0634 | 0.0991 | 0.1035 | 0.0632 | 0.0706 | 0.0877 | 0.0978 | 0.6783 | 0.6519 | 0.0001 | 0.0011 | 0.0020 | 0.0119 | 0.0542 | 0.0904 | 0.0605 | 0.0819 | 0.6977 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 1163 | 489 | 321 | 5383 | 116.6 | 17.58 | 10.59 | 16.86 | 93 | 99 | 105 | 110 | 115 | 122 | 128 | 133 | 140 | 0.0832 | 448 | 1.174 | 34.48 | 13.89 | 3 | 0.2897 | 93 | 0.0412 | 1.34 | 3.375 | 0.6192 | 13896.5 | 1690000 | 210000000 | 26600000000 | 0.3932 | 0.2232 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0116 | 0.0000 | 0.0388 | 0.0156 | 0.0930 | 0.0498 | 0.1395 | 0.1090 | 0.1395 | 0.0592 | 0.1938 | 0.0935 | 0.3837 | 0.6729 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0069 | 0.0000 | 0.0243 | 0.0156 | 0.0590 | 0.0498 | 0.1007 | 0.1090 | 0.0833 | 0.0592 | 0.1111 | 0.0935 | 0.6146 | 0.6729 | 0.0333 | 0.0000 | 0.0667 | 0.0000 | 0.0333 | 0.0000 | 0.1667 | 0.0000 | 0.2667 | 0.0000 | 0.2000 | 0.0000 | 0.1000 | 0.0000 | 0.1000 | 0.0000 | 0.0333 | 0.0000 | 0.0000 | 0.0000 | 0.0258 | 0.0516 | 0.0839 | 0.1290 | 0.0710 | 0.1032 | 0.5355 | 3 | 5 | 6 | 6 | 7 | 8 | 9 | 10 | 13 | 0.1037 | 0.50 | 1.327 | 0.4010 | 396.2 | 39837.1 | 5690000 | 976000000 | 0.5867 | 0.1158 | 0.1081 | 0.0234 | 0.1521 | 0.0646 | 0.1822 | 0.1055 | 0.1683 | 0.1248 | 0.1992 | 0.1564 | 0.1228 | 0.1745 | 0.0533 | 0.1681 | 0.0139 | 0.1293 | 0.0000 | 0.0533 | 0.0717 | 0.0199 | 0.1019 | 0.0545 | 0.1150 | 0.0857 | 0.0980 | 0.0980 | 0.1194 | 0.1193 | 0.1073 | 0.1330 | 0.0772 | 0.1375 | 0.0728 | 0.1248 | 0.2366 | 0.2273 | 0.0433 | 0.0158 | 0.0226 | 0.0204 | 0.0377 | 0.0226 | 0.0377 | 0.0385 | 0.0734 | 0.0973 | 0.1092 | 0.1154 | 0.0923 | 0.0905 | 0.1224 | 0.1222 | 0.4614 | 0.4774 | 0.1188 | 0.1103 | 0.0827 | 0.0562 | 0.0615 | 0.0679 | 0.0679 | 0.0933 | 0.3415 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 293 | 609 | 8337 | 19608 | 101.9 | 24.16 | 175.88 | 142.47 | 73 | 81 | 88 | 94 | 100 | 105 | 112 | 120 | 133 | 0.0523 | 1025 | 1.074 | 109.56 | 38.12 | 1 | 0.0356 | 297 | 0.0033 | 13.03 | 6.018 | 0.3011 | 10963.8 | 1250000 | 150000000 | 19200000000 | 0.4490 | 0.2070 | 0.0004 | 0.0001 | 0.0023 | 0.0001 | 0.0097 | 0.0004 | 0.0284 | 0.0036 | 0.0817 | 0.0181 | 0.1470 | 0.0410 | 0.1702 | 0.0513 | 0.1762 | 0.0783 | 0.3842 | 0.8070 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0032 | 0.0002 | 0.0086 | 0.0011 | 0.0365 | 0.0115 | 0.0679 | 0.0245 | 0.0709 | 0.0208 | 0.1034 | 0.0398 | 0.7091 | 0.9020 | 0.0034 | 0.0064 | 0.0135 | 0.0451 | 0.0310 | 0.0579 | 0.1018 | 0.1373 | 0.1415 | 0.1803 | 0.1894 | 0.1717 | 0.1240 | 0.0880 | 0.1388 | 0.1652 | 0.2567 | 0.1481 | 0.0010 | 0.0026 | 0.0126 | 0.0419 | 0.0856 | 0.1309 | 0.1186 | 0.1404 | 0.4663 | 19 | 44 | 74 | 106 | 143 | 186 | 235 | 291 | 376 | 0.0029 | 66.47 | 7.155 | 0.2685 | 51228.7 | 19100000 | 8380000000 | 4150000000000 | 0.4441 | 0.1782 | 0.0134 | 0.0030 | 0.0694 | 0.0074 | 0.1927 | 0.0268 | 0.1717 | 0.0701 | 0.1818 | 0.1554 | 0.1490 | 0.1966 | 0.0920 | 0.1467 | 0.0742 | 0.1533 | 0.0557 | 0.2406 | 0.0008 | 0.0005 | 0.0013 | 0.0013 | 0.0030 | 0.0031 | 0.0128 | 0.0102 | 0.0442 | 0.0384 | 0.0810 | 0.0621 | 0.0713 | 0.0562 | 0.1002 | 0.0808 | 0.6853 | 0.7475 | 0.0015 | 0.0011 | 0.0021 | 0.0051 | 0.0067 | 0.0130 | 0.0204 | 0.0276 | 0.0725 | 0.0848 | 0.1212 | 0.1448 | 0.1025 | 0.1133 | 0.1303 | 0.1466 | 0.5429 | 0.4637 | 0.0005 | 0.0020 | 0.0054 | 0.0154 | 0.0553 | 0.1015 | 0.0850 | 0.1150 | 0.6199 | |||
BT-20 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1099 | 456 | 4384 | 11255 | 330.4 | 82.17 | 122.23 | 126.09 | 224 | 258 | 283 | 305 | 326 | 347 | 372 | 400 | 446 | 0.0782 | 880 | 1.074 | 91.24 | 29.15 | 1 | 0.0527 | 231 | 0.0005 | 119.89 | 7.749 | 0.1150 | 115898.0 | 42900000 | 16600000000 | 6700000000000 | 0.4213 | 0.2264 | 0.0004 | 0.0003 | 0.0004 | 0.0000 | 0.0020 | 0.0008 | 0.0145 | 0.0036 | 0.0912 | 0.0281 | 0.1739 | 0.0521 | 0.1546 | 0.0521 | 0.1784 | 0.0727 | 0.3846 | 0.7904 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0006 | 0.0002 | 0.0038 | 0.0012 | 0.0353 | 0.0176 | 0.0695 | 0.0312 | 0.0601 | 0.0279 | 0.0917 | 0.0391 | 0.7384 | 0.8827 | 0.0032 | 0.0063 | 0.0032 | 0.0158 | 0.0222 | 0.0095 | 0.0549 | 0.0886 | 0.1267 | 0.1203 | 0.1426 | 0.2089 | 0.0971 | 0.1582 | 0.1204 | 0.1487 | 0.4298 | 0.2437 | 0.0019 | 0.0024 | 0.0081 | 0.0276 | 0.0676 | 0.1257 | 0.0995 | 0.1185 | 0.5488 | 12 | 17 | 26 | 41 | 66 | 110 | 167 | 231 | 315 | 0.0244 | 16.78 | 5.456 | 0.4535 | 30835.4 | 10200000 | 3890000000 | 1660000000000 | 0.5357 | 0.1392 | 0.0679 | 0.0019 | 0.2575 | 0.0224 | 0.3413 | 0.1296 | 0.1487 | 0.2072 | 0.0978 | 0.2115 | 0.0459 | 0.1648 | 0.0279 | 0.1034 | 0.0120 | 0.0858 | 0.0010 | 0.0734 | 0.0000 | 0.0000 | 0.0013 | 0.0002 | 0.0025 | 0.0033 | 0.0197 | 0.0144 | 0.0659 | 0.0599 | 0.1055 | 0.0938 | 0.0848 | 0.0719 | 0.1153 | 0.1097 | 0.6050 | 0.6468 | 0.0013 | 0.0012 | 0.0024 | 0.0024 | 0.0109 | 0.0115 | 0.0270 | 0.0329 | 0.0840 | 0.0922 | 0.1224 | 0.1351 | 0.1038 | 0.1031 | 0.1234 | 0.1278 | 0.5248 | 0.4938 | 0.0000 | 0.0014 | 0.0058 | 0.0175 | 0.0782 | 0.1175 | 0.0896 | 0.1249 | 0.5651 |